Referenced in: none

Automatically associated channels: ClC3 , ClC4

Title: CLC-3 chloride channels in the pulmonary vasculature.

Authors: Joseph R Hume, Ge-Xin Wang, Jun Yamazaki, Lih Chyuan Ng, Dayue Duan

Journal, date & volume: Adv. Exp. Med. Biol., 2010 , 661, 237-47

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20204734

Abstract
Volume-sensitive outwardly rectifying anion channels (VSOACs) are expressed in pulmonary artery smooth muscle cells (PASMCs) and have been implicated in cell proliferation, growth, apoptosis and protection against oxidative stress. In this chapter, we review the properties of native VSOACs in PASMCs, and consider the evidence that ClC-3, a member of the ClC superfamily of voltage dependent Cl- channels, may be responsible for native VSOACs in PASMCs. Finally, we examine whether or not native VSOACs and heterologously expressed ClC-3 channels function as bona fide chloride channels or as chloride/proton antiporters.