Referenced in: none

Automatically associated channels: ClC4 , ClC7 , Slo1

Title: A role for chloride transport in lysosomal protein degradation.

Authors: Lena Wartosch, Tobias Stauber

Journal, date & volume: Autophagy, 2010 Jan , 6, 158-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20104020

Abstract
Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.