Channelpedia

PubMed 20104020


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: ClvC4 , ClvC7 , Slo1



Title: A role for chloride transport in lysosomal protein degradation.

Authors: Lena Wartosch, Tobias Stauber

Journal, date & volume: Autophagy, 2010 Jan , 6, 158-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20104020


Abstract
Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.