Channelpedia

PubMed 15052463


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: ClvC4 , ClvC5



Title: Examination of megalin in renal tubular epithelium from patients with Dent disease.

Authors: Yoko Santo, Haruhiko Hirai, Masaaki Shima, Masayo Yamagata, Toshimi Michigami, Shigeo Nakajima, Keiichi Ozono

Journal, date & volume: Pediatr. Nephrol., 2004 Jun , 19, 612-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15052463


Abstract
Dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of disturbed megalin expression, which is a member of the low-density lipoprotein receptor family and is associated with renal reabsorption of a variety of proteins, in Dent disease. We examined the expression of megalin in the renal tubular epithelium of two unrelated patients with Dent disease. One patient, whose CLCN5 gene was completely deleted, showed significantly decreased staining of megalin compared with controls, while there was no change in another patient with partial deletion of the gene. These results demonstrated that mutation of CLCN5 in some patients with Dent disease may impair the expression of megalin, resulting in abnormal calcium metabolism, manifested as hypercalciuria and nephrocalcinosis.