PubMed 17698007

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav1.2 , Cav1.3 , Kv10.1

Title: Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane.

Authors: Diego Varela, Gerald W Zamponi

Journal, date & volume: Neuron, 2007 Aug 16 , 55, 539-41

PubMed link:

Calcium influx via L-type (Cav1.2 and Cav1.3) calcium channels is tightly regulated to ensure optimal intracellular calcium levels. Although much is known about acute modulation of these channels by second messengers, the mechanisms that control their trafficking to and from the plasma membrane remain poorly understood. In this issue of Neuron, Green and colleagues demonstrate that the opening of L-type calcium channels results in negative feedback regulation due to their calcium-dependent internalization.