Channelpedia

PubMed 18756294


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav3.1 , Kv10.1 , Slo1



Title: Let's look at cysts from both sides now.

Authors: Seth L Alper

Journal, date & volume: Kidney Int., 2008 Sep , 74, 699-702

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18756294


Abstract
In the years since identification of autosomal-dominant polycystic kidney disease (ADPKD) genes, the lag time between initial understanding and translation to therapy has decreased rapidly. Albaqumi and colleagues describe a promising approach to slow ADPKD cyst enlargement through inhibition of the basolateral KCa3.1 K(+) channel, using a nontoxic small molecule with a close congener poised for rapid entry into the clinic. Cyst fluid accumulation can be blocked from both sides now.