Channelpedia

PubMed 19447085


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv10.1



Title: Rethinking how hearing happens.

Authors: Zhigang Xu, Anthony J Ricci, Stefan Heller

Journal, date & volume: Neuron, 2009 May 14 , 62, 305-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19447085


Abstract
Inner ear hair cells convert hair bundle deflection into mechanical force sensed by ion channels via extracellular tip links between adjacent stereocilia. In this Neuron issue, Grillet and colleagues show the protein harmonin mechanically reinforces tip link upper insertion sites. Harmonin loss at this site reduces mechanotransduction kinetics and sensitivity.