Referenced in: none

Automatically associated channels: Kv10.1

Title: Traffic jams during vesicle cycling lead to synaptic depression.

Authors: Jun Hee Kim, Henrique von Gersdorff

Journal, date & volume: Neuron, 2009 Jul 30 , 63, 143-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19640472

Abstract
During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca2+](i)-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.