Channelpedia

PubMed 19751314


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: ClvC1 , ClvC4



Title: Statins and fibrate target ClC-1 - from side effects to CLC pharmacology.

Authors: Anselm A Zdebik

Journal, date & volume: Br. J. Pharmacol., 2009 Apr , 156, 1204-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19751314


Abstract
Lipid-lowering drugs have been associated with severe adverse effects on skeletal muscle, including rhabdomyolysis. More common symptoms include cramps and myalgia. In this issue of the BJP, Pierno et al. find that two statins and fenofibrate, often used in combination, decrease function of the chloride channel member 1 of the mammalian CLC protein family of chloride channels and transporters in skeletal muscle by three distinct mechanisms. Other compounds have recently been shown to potently modulate the pharmacologically less well-explored CLC protein family, which comprises chloride channels and chloride/proton antiporters. These findings may well lead to a new era of CLC protein pharmacology.