Channelpedia

PubMed 19968958


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.1 , Kv1.4



Title: Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.

Authors: Hyder Usman, M K Mathew

Journal, date & volume: Biochem. Biophys. Res. Commun., 2010 Jan 15 , 391, 1301-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19968958


Abstract
Besides their role in the generation of action potentials, voltage-gated potassium channels are implicated in cellular processes ranging from cell division to cell death. The K(+) channel regulator protein (KCNRG), identified as a putative tumor suppressor, reduces K(+) currents through human K(+) channels hKv1.1 and hKv1.4 expressed in Xenopus oocytes. Current attenuation requires the presence of the N-terminal T1 Domain and immunoprecipitation experiments suggest association of KCNRG with the N-terminus of the channel. Our data indicates that KCNRG is an ER-associated protein, which we propose regulates Kv1 family channel proteins by retaining a fraction of channels in endomembranes.