PubMed 19717445

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv2.1

Title: Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence.

Authors: Jamel Mankouri, Mark L Dallas, Mair E Hughes, Stephen D C Griffin, Andrew Macdonald, Chris Peers, Mark Harris

Journal, date & volume: Proc. Natl. Acad. Sci. U.S.A., 2009 Sep 15 , 106, 15903-8

PubMed link:

An estimated 3% of the global population are infected with hepatitis C virus (HCV), and the majority of these individuals will develop chronic liver disease. As with other chronic viruses, establishment of persistent infection requires that HCV-infected cells must be refractory to a range of pro-apoptotic stimuli. In response to oxidative stress, amplification of an outward K(+) current mediated by the Kv2.1 channel, precedes the onset of apoptosis. We show here that in human hepatoma cells either infected with HCV or harboring an HCV subgenomic replicon, oxidative stress failed to initiate apoptosis via Kv2.1. The HCV NS5A protein mediated this effect by inhibiting oxidative stress-induced p38 MAPK phosphorylation of Kv2.1. The inhibition of a host cell K(+) channel by a viral protein is a hitherto undescribed viral anti-apoptotic mechanism and represents a potential target for antiviral therapy.