Referenced in: none

Automatically associated channels: Kir1.1 , Kir6.2

Title: Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.

Authors: Norihide Yokoi, Masao Kanamori, Yukio Horikawa, Jun Takeda, Tokio Sanke, Hiroto Furuta, Kishio Nanjo, Hiroyuki Mori, Masato Kasuga, Kazuo Hara, Takashi Kadowaki, Yukio Tanizawa, Yoshitomo Oka, Yukiko Iwami, Hisako Ohgawara, Yuichiro Yamada, Yutaka Seino, Hideki Yano, Nancy J Cox, Susumu Seino

Journal, date & volume: Diabetes, 2006 Aug , 55, 2379-86

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16873704

Abstract
Because impaired insulin secretion is characteristic of type 2 diabetes in Asians, including Japanese, the genes involved in pancreatic beta-cell function are candidate susceptibility genes for type 2 diabetes. We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. The exon 16 -3c/t variant rs1799854 in ABCC8 showed a significant association (P = 0.0073), and variants in several genes showed nominally significant associations (P < 0.05) with type 2 diabetes. Although the E23K variant rs5219 in KCNJ11 showed no association with diabetes in Japanese (for the K allele, odds ratio [OR] 1.08 [95% CI 0.97-1.21], P = 0.15), 95% CI around the OR overlaps in meta-analysis of European populations, suggesting that our results are not inconsistent with the previous studies. This is the largest association study so far conducted on these genes in Japanese and provides valuable information for comparison with other ethnic groups.