Channelpedia

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels.


Authors: A Butler, S Tsunoda, D P McCobb, A Wei, L Salkoff

Journal, date & volume: Science, 1993 Jul 9 , 261, 221-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/7687074

Channelpedia reference in: Slo3

Abstract
Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.