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PubMed 2456612


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Title: The coupling of neurotransmitter receptors to ion channels in the brain.

Authors: R A Nicoll

Journal, date & volume: Science, 1988 Jul 29 , 241, 545-51

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2456612


Abstract

Recent studies on the action of neurotransmitters on hippocampal pyramidal cells indicate that different neurotransmitter receptors that use either the same or different coupling mechanisms converge onto the same ion channel. Conversely, virtually all of the neurotransmitters act on at least two distinct receptor subtypes coupled to different ion channels on the same cell. The existence of both convergence and divergence in the action of neurotransmitters results in a remarkable diversity in neuronal signaling.