Channelpedia

HCN4 Channel

384 automatically matched literature references

4

Mezzano V et al. Desmosomal junctions are necessary for adult sinus node function.
Cardiovasc. Res., 2016 Apr 20 , ().

6

Liu J et al. Effects of Yiqi Tongyang on HCN4 Protein Phosphorylation in Damaged Rabbit Sinoatrial Node Cells.
Evid Based Complement Alternat Med, 2016 , 2016 (4379139).

7

Huang X et al. Age-associated expression of HCN channel isoforms in rat sinoatrial node.
Exp. Biol. Med. (Maywood), 2015 Sep 3 , ().

10

Li N et al. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1219-27).

13

O'Donnell AM et al. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
World J. Gastroenterol., 2015 May 14 , 21 (5635-40).

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20

Liang X et al. Insights into cardiac conduction system formation provided by HCN4 expression.
Trends Cardiovasc. Med., 2015 Jan , 25 (1-9).

22

Huang J et al. PP2 prevents isoproterenol stimulation of cardiac pacemaker activity.
J. Cardiovasc. Pharmacol., 2015 Feb , 65 (193-202).

23

Chen XF et al. [Changes of HCN4, Cx43 Expression in the Sinoatrial Node of Electric Shock Death].
Fa Yi Xue Za Zhi, 2015 Aug , 31 (266-8).

27

Fürst O et al. Isoform dependent regulation of human HCN channels by cholesterol.
Sci Rep, 2015 , 5 (14270).

28

Günther A et al. Distinct expression patterns of HCN channels in HL-1 cardiomyocytes.
BMC Cell Biol., 2015 , 16 (18).

37

Lai MH et al. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.
Am. J. Physiol. Heart Circ. Physiol., 2014 Nov 1 , 307 (H1327-38).

40

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44

Mackiewicz U et al. Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat.
J. Cell. Physiol., 2014 Jun , 229 (813-23).

45

Lolicato M et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nat. Chem. Biol., 2014 Jun , 10 (457-62).

47

Huang J et al. PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.
J. Cardiovasc. Pharmacol., 2014 Jun , 63 (533-43).

50

54

55

58

Mesirca P et al. T-type channels in the sino-atrial and atrioventricular pacemaker mechanism.
Pflugers Arch., 2014 Apr , 466 (791-9).

63

67

St Clair JR et al. PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes.
Channels (Austin), 2013 Jul-Aug , 7 (318-21).

68

DiFrancesco D Funny channel gene mutations associated with arrhythmias.
J. Physiol. (Lond.), 2013 Sep 1 , 591 (4117-24).

72

Chiu SN et al. Long-term outcomes of pediatric sinus bradycardia.
J. Pediatr., 2013 Sep , 163 (885-9.e1).

75

Nawathe PA et al. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.
J. Cardiovasc. Electrophysiol., 2013 Sep , 24 (1021-7).

77

Hashem SI et al. Shox2 regulates the pacemaker gene program in embryoid bodies.
Stem Cells Dev., 2013 Nov 1 , 22 (2915-26).

85

Hashem SI et al. Genetic isolation of stem cell-derived pacemaker-nodal cardiac myocytes.
Mol. Cell. Biochem., 2013 Jul 23 , ().

86

Sah R et al. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 22 , ().

87

93

Fenske S et al. Sick Sinus Syndrome in HCN1-Deficient Mice.
Circulation, 2013 Dec 17 , 128 (2585-94).

96

Stillitano F et al. Chronic atrial fibrillation alters the functional properties of If in the human atrium.
J. Cardiovasc. Electrophysiol., 2013 Dec , 24 (1391-400).

97

Stevens SM et al. HCN4 charges up the first heart field.
Circ. Res., 2013 Aug 2 , 113 (350-1).

99

Liang X et al. HCN4 dynamically marks the first heart field and conduction system precursors.
Circ. Res., 2013 Aug 2 , 113 (399-407).

104

115

Herrmann S et al. HCN channels in the heart: lessons from mouse mutants.
Br. J. Pharmacol., 2012 May , 166 (501-9).

121

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134

Chen Y et al. Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents.
Alcohol. Clin. Exp. Res., 2012 Dec , 36 (2036-46).

135

136

Hofmann F et al. Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.
Cardiovasc. Res., 2012 Aug 1 , 95 (317-26).

137

140

Lippi G et al. Genetic and clinical aspects of Brugada syndrome: an update.
Adv Clin Chem, 2012 , 56 (197-208).

142

Scicchitano P et al. HCN channels and heart rate.
Molecules, 2012 , 17 (4225-35).

143

Speranza L et al. The biological effects of ivabradine in cardiovascular disease.
Molecules, 2012 , 17 (4924-35).

146

149

Liao Z et al. Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes.
Channels (Austin), 2011 Mar-Apr , 5 (115-9).

150

Fenske S et al. HCN3 contributes to the ventricular action potential waveform in the murine heart.
Circ. Res., 2011 Oct 14 , 109 (1015-23).

155

Fenske S et al. The role of HCN channels in ventricular repolarization.
Trends Cardiovasc. Med., 2011 Nov , 21 (216-20).

159

Puller C et al. Bipolar cells of the ground squirrel retina.
J. Comp. Neurol., 2011 Mar 1 , 519 (759-74).

160

Cain JE et al. GLI3 repressor controls functional development of the mouse ureter.
J. Clin. Invest., 2011 Mar 1 , 121 (1199-206).

162

Kelmendi B et al. Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder.
Neurosci. Lett., 2011 Jun 8 , 496 (195-9).

166

Bogdan R et al. Effect of dronedarone on Na(+), Ca (2+) and HCN channels.
, 2011 Jan 29 , ().

168

Baruscotti M et al. Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.
Proc. Natl. Acad. Sci. U.S.A., 2011 Jan 25 , 108 (1705-10).

172

Ye Sheng X et al. Isolation and characterization of atrioventricular nodal cells from neonate rabbit heart.
Circ Arrhythm Electrophysiol, 2011 Dec , 4 (936-46).

173

Herrmann S et al. Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
J. Mol. Cell. Cardiol., 2011 Dec , 51 (997-1006).

175

Klöckner U et al. Differential reduction of HCN channel activity by various types of lipopolysaccharide.
J. Mol. Cell. Cardiol., 2011 Aug , 51 (226-35).

177

Vicente-Steijn R et al. Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart.
Heart Rhythm, 2011 Aug , 8 (1254-63).

178

Liu H et al. Tissue-specific N terminus of the HCN4 channel affects channel activation.
J. Biol. Chem., 2011 Apr 22 , 286 (14209-14).

179

Herrmann S et al. Insights into sick sinus syndrome from an inducible mouse model.
Cardiovasc. Res., 2011 Apr 1 , 90 (38-48).

181

Sako H et al. Establishment of clonal cell lines of taste buds from a p53(-/-) mouse tongue.
In Vitro Cell. Dev. Biol. Anim., 2011 Apr , 47 (333-40).

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Xu X et al. Structural basis for the cAMP-dependent gating in the human HCN4 channel.
J. Biol. Chem., 2010 Nov 19 , 285 (37082-91).

187

Sun LP et al. Effects of Shensong Yangxin capsule on pacemaker channels encoded by human HCN4 gene.
Chin. Med. J., 2010 Nov , 123 (3148-50).

197

Baruscotti M et al. HCN-related channelopathies.
Pflugers Arch., 2010 Jul , 460 (405-15).

200

Baruscotti M et al. The cardiac pacemaker current.
J. Mol. Cell. Cardiol., 2010 Jan , 48 (55-64).

202

DiFrancesco D The role of the funny current in pacemaker activity.
Circ. Res., 2010 Feb 19 , 106 (434-46).

204

Yanni J et al. Structural remodelling of the sinoatrial node in obese old rats.
J. Mol. Cell. Cardiol., 2010 Apr , 48 (653-62).

205

Liang H et al. Electrophysiological basis of the first heart beats.
Cell. Physiol. Biochem., 2010 , 25 (561-70).

206

Thollon C et al. I(f) inhibition in cardiovascular diseases.
Adv. Pharmacol., 2010 , 59 (53-92).

207

Zhang J et al. Cardiac stem cells differentiate into sinus node-like cells.
Tohoku J. Exp. Med., 2010 , 222 (113-20).

209

Kuratomi S et al. The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2.
Cardiovasc. Res., 2009 Sep 1 , 83 (682-7).

212

Nof E et al. The Contribution of HCN4 to Normal Sinus Node Function in Humans and Animal Models.
Pacing Clin Electrophysiol, 2009 Oct 1 , ().

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Gassanov N et al. Distinct regulation of cardiac I(f) current via thyroid receptors alpha1 and beta1.
Pflugers Arch., 2009 Oct , 458 (1061-8).

217

Schweizer PA et al. Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.
Basic Res. Cardiol., 2009 May 7 , ().

218

Zhang Q et al. Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Biochim. Biophys. Acta, 2009 May , 1788 (1138-47).

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Yanni J et al. The extent of the specialized atrioventricular ring tissues.
Heart Rhythm, 2009 May , 6 (672-80).

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Greener ID et al. Ion channel transcript expression at the rabbit atrioventricular conduction axis.
Circ Arrhythm Electrophysiol, 2009 Jun , 2 (305-15).

230

Alig J et al. Control of heart rate by cAMP sensitivity of HCN channels.
Proc. Natl. Acad. Sci. U.S.A., 2009 Jul 21 , 106 (12189-94).

231

Brandt MC et al. Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties.
Am. J. Physiol. Heart Circ. Physiol., 2009 Jul , 297 (H355-63).

235

Ueda K et al. Role of HCN4 channel in preventing ventricular arrhythmia.
J. Hum. Genet., 2009 Feb , 54 (115-21).

236

Brioschi C et al. Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.
J. Mol. Cell. Cardiol., 2009 Aug , 47 (221-7).

238

Wu Y et al. Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Proc. Natl. Acad. Sci. U.S.A., 2009 Apr 7 , 106 (5972-7).

241

Gao N et al. Voltage-gated sodium channels in taste bud cells.
, 2009 , 10 (20).

243

Wickenden AD et al. HCN pacemaker channels and pain: a drug discovery perspective.
Curr. Pharm. Des., 2009 , 15 (2149-68).

245

Yang XJ et al. Mesenchymal stem cells as a gene delivery system to create biological pacemaker cells in vitro.
J. Int. Med. Res., 2008 Sep-Oct , 36 (1049-55).

246

Balijepalli RC et al. Caveolae, ion channels and cardiac arrhythmias.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (149-60).

247

Oi H et al. HCN4-like immunoreactivity in rat retinal ganglion cells.
Vis. Neurosci., 2008 Jan-Feb , 25 (95-102).

248

251

Li HX et al. [The changes of funny currents in the ventricular myocytes of neonatal rats and adult rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2008 Nov , 24 (411-5).

254

Barbuti A et al. Control of cardiac rate by "funny" channels in health and disease.
Ann. N. Y. Acad. Sci., 2008 Mar , 1123 (213-23).

257

Hardel N et al. Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.
Cardiovasc. Res., 2008 Jul 1 , 79 (52-60).

259

Hoesl E et al. Tamoxifen-inducible gene deletion in the cardiac conduction system.
J. Mol. Cell. Cardiol., 2008 Jul , 45 (62-9).

260

Li CH et al. Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531.
Am. J. Physiol., Cell Physiol., 2008 Jan , 294 (C355-62).

266

Momin A et al. Role of the hyperpolarization-activated current Ih in somatosensory neurons.
J. Physiol. (Lond.), 2008 Dec 15 , 586 (5911-29).

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Stillitano F et al. Molecular basis of funny current (If) in normal and failing human heart.
J. Mol. Cell. Cardiol., 2008 Aug , 45 (289-99).

269

Vemana S et al. Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.
Am. J. Physiol., Cell Physiol., 2008 Aug , 295 (C557-65).

273

Huang X et al. Age-related down-regulation of HCN channels in rat sinoatrial node.
Basic Res. Cardiol., 2007 Sep , 102 (429-35).

276

Muto T et al. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes.
Am. J. Physiol. Heart Circ. Physiol., 2007 Nov , 293 (H2710-8).

277

Viswanathan S et al. Characterization of sinoatrial node in four conduction system marker mice.
J. Mol. Cell. Cardiol., 2007 May , 42 (946-53).

281

Liu J et al. Organisation of the mouse sinoatrial node: structure and expression of HCN channels.
Cardiovasc. Res., 2007 Mar 1 , 73 (729-38).

283

Yu X et al. Calcium influx through If channels in rat ventricular myocytes.
Am. J. Physiol., Cell Physiol., 2007 Mar , 292 (C1147-55).

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Herrmann S et al. Pathophysiology of HCN channels.
Pflugers Arch., 2007 Jul , 454 (517-22).

291

Kuratomi S et al. NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
Biochem. Biophys. Res. Commun., 2007 Feb 2 , 353 (67-73).

292

Mommersteeg MT et al. Molecular pathway for the localized formation of the sinoatrial node.
Circ. Res., 2007 Feb 16 , 100 (354-62).

293

Ishii TM et al. Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.
Biochem. Biophys. Res. Commun., 2007 Aug 3 , 359 (592-8).

298

DiFrancesco D et al. The funny current: cellular basis for the control of heart rate.
Drugs, 2007 , 67 Suppl 2 (15-24).

299

Varghese A et al. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.
Prog. Biophys. Mol. Biol., 2006 Jan-Apr , 90 (26-37).

301

Elinder F et al. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.
J. Physiol. (Lond.), 2006 Sep 1 , 575 (417-31).

304

Zhong YM et al. [Transfecting rat heart with human pacemaker gene in vivo to create a biological pacemaker]
Zhonghua Yi Xue Za Zhi, 2006 Oct 31 , 86 (2831-5).

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Fernández-Velasco M et al. I K1 and I f in ventricular myocytes isolated from control and hypertrophied rat hearts.
Pflugers Arch., 2006 May , 452 (146-54).

312

Milanesi R et al. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
N. Engl. J. Med., 2006 Jan 12 , 354 (151-7).

315

Kuisle M et al. Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.
J. Physiol. (Lond.), 2006 Aug 15 , 575 (83-100).

316

Bucchi A et al. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.
J. Physiol. (Lond.), 2006 Apr 15 , 572 (335-46).

320

Bajorat R et al. Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages.
J. Neurosci. Res., 2005 Oct 15 , 82 (206-13).

321

Stieber J et al. Functional expression of the human HCN3 channel.
J. Biol. Chem., 2005 Oct 14 , 280 (34635-43).

322

Hucker WJ et al. Optical mapping of the atrioventricular junction.
, 2005 Oct , 38 (121-5).

327

Marionneau C et al. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.
J. Physiol. (Lond.), 2005 Jan 1 , 562 (223-34).

333

Gravante B et al. Interaction of the pacemaker channel HCN1 with filamin A.
J. Biol. Chem., 2004 Oct 15 , 279 (43847-53).

334

Efimov IR et al. Structure-function relationship in the AV junction.
, 2004 Oct , 280 (952-65).

336

Barbuti A et al. Localization of pacemaker channels in lipid rafts regulates channel kinetics.
Circ. Res., 2004 May 28 , 94 (1325-31).

337

Feigenspan A et al. Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
J. Neurosci., 2004 Mar 31 , 24 (3325-34).

342

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Stieber J et al. Pacemaker channels and sinus node arrhythmia.
Trends Cardiovasc. Med., 2004 Jan , 14 (23-8).

344

Notomi T et al. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
J. Comp. Neurol., 2004 Apr 5 , 471 (241-76).

346

Stieber J et al. Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.
J. Biol. Chem., 2003 Sep 5 , 278 (33672-80).

348

Borlak J et al. Hallmarks of ion channel gene expression in end-stage heart failure.
FASEB J., 2003 Sep , 17 (1592-608).

350

Pál B et al. HCN channels contribute to the intrinsic activity of cochlear pyramidal cells.
Cell. Mol. Life Sci., 2003 Oct , 60 (2189-99).

352

353

Swanson EA et al. Cardiac expression and function of thyroid hormone receptor beta and its PV mutant.
Endocrinology, 2003 Nov , 144 (4820-5).

354

Schulze-Bahr E et al. Pacemaker channel dysfunction in a patient with sinus node disease.
J. Clin. Invest., 2003 May , 111 (1537-45).

355

365

Qu J et al. Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.
Pflugers Arch., 2002 Aug , 444 (597-601).

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Ishii TM et al. Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels.
J. Physiol. (Lond.), 2001 Nov 15 , 537 (93-100).

368

Yasui K et al. I(f) current and spontaneous activity in mouse embryonic ventricular myocytes.
Circ. Res., 2001 Mar 16 , 88 (536-42).

370

Altomare C et al. Integrated allosteric model of voltage gating of HCN channels.
J. Gen. Physiol., 2001 Jun , 117 (519-32).

376

Monteggia LM et al. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.
Brain Res. Mol. Brain Res., 2000 Sep 30 , 81 (129-39).

380

Moosmang S et al. Differential distribution of four hyperpolarization-activated cation channels in mouse brain.
Biol. Chem., 1999 Jul-Aug , 380 (975-80).

384

Ludwig A et al. A family of hyperpolarization-activated mammalian cation channels.
Nature, 1998 Jun 11 , 393 (587-91).