Channelpedia

HCN2 Channel

405 automatically matched literature references

1

Hayashi K et al. Green apatites: hydride ions, electrons and their interconversion in the crystallographic channel.
Phys Chem Chem Phys, 2016 Mar 9 , 18 (8186-95).

2

Deberg HA et al. Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.
J. Biol. Chem., 2016 Jan 1 , 291 (371-81).

4

Huang X et al. Age-associated expression of HCN channel isoforms in rat sinoatrial node.
Exp. Biol. Med. (Maywood), 2015 Sep 3 , ().

8

Li N et al. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1219-27).

10

O'Donnell AM et al. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
World J. Gastroenterol., 2015 May 14 , 21 (5635-40).

15

Oshita K et al. Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.
J. Mol. Cell. Cardiol., 2015 Mar , 80 (81-9).

17

23

Pittoors F et al. HCN2 channels: a permanent open state and conductance changes.
J. Membr. Biol., 2015 Feb , 248 (67-81).

24

Galaz P et al. Advances in the pharmacology of lGICs auxiliary subunits.
Pharmacol. Res., 2015 Aug 7 , ().

28

Kopp-Scheinpflug C et al. Nitric oxide selectively suppresses IH currents mediated by HCN1-containing channels.
J. Physiol. (Lond.), 2015 Apr 1 , 593 (1685-700).

29

DiFrancesco JC et al. Dysfunctional HCN ion channels in neurological diseases.
Front Cell Neurosci, 2015 , 6 (174).

30

Fürst O et al. Isoform dependent regulation of human HCN channels by cholesterol.
Sci Rep, 2015 , 5 (14270).

31

Günther A et al. Distinct expression patterns of HCN channels in HL-1 cardiomyocytes.
BMC Cell Biol., 2015 , 16 (18).

36

Saponaro A et al. Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Proc. Natl. Acad. Sci. U.S.A., 2014 Oct 7 , 111 (14577-82).

37

Yang YC et al. Dexmedetomidine produced analgesic effect via inhibition of HCN currents.
Eur. J. Pharmacol., 2014 Oct 5 , 740 (560-4).

42

44

Kodan A et al. Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.
Proc. Natl. Acad. Sci. U.S.A., 2014 Mar 18 , 111 (4049-54).

49

Shah MM Cortical HCN channels: function, trafficking and plasticity.
J. Physiol. (Lond.), 2014 Jul 1 , 592 (2711-9).

50

51

Thon S et al. Avoiding the formation of vesicles by patch excision from Xenopus oocytes.
J. Neurosci. Methods, 2014 Jan 20 , ().

53

Gofman Y et al. Structure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channel.
PLoS Comput. Biol., 2014 Dec , 10 (e1003976).

62

Williams TA et al. Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas.
Hypertension, 2013 Sep 30 , ().

66

Nawathe PA et al. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.
J. Cardiovasc. Electrophysiol., 2013 Sep , 24 (1021-7).

68

Carlson AE et al. Flavonoid regulation of HCN2 channels.
J. Biol. Chem., 2013 Oct 1 , ().

69

Thon S et al. Elementary functional properties of single HCN2 channels.
Biophys. J., 2013 Oct 1 , 105 (1581-9).

70

Zagidullin NSh et al. [Direct evidences of calcium traffic through pacemaker channel].
Ross Fiziol Zh Im I M Sechenova, 2013 Oct , 99 (1175-80).

71

Zagidullin NSh et al. [Direct evidences of calcium traffic through pacemaker channel].
Ross Fiziol Zh Im I M Sechenova, 2013 Oct , 99 (1175-80).

72

Monticone S et al. a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.
J. Clin. Endocrinol. Metab., 2013 Nov , 98 (E1861-5).

76

Du L et al. The role of HCN channels within the periaqueductal gray in neuropathic pain.
Brain Res., 2013 Mar 15 , 1500 (36-44).

81

Chowdhury S et al. Free-energy relationships in ion channels activated by voltage and ligand.
J. Gen. Physiol., 2013 Jan , 141 (11-28).

98

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Benndorf K et al. Unraveling subunit cooperativity in homotetrameric HCN2 channels.
Biophys. J., 2012 Nov 7 , 103 (1860-9).

101

Wemhöner K et al. A leucine zipper motif essential for gating of hyperpolarization-activated channels.
J. Biol. Chem., 2012 Nov 23 , 287 (40150-60).

105

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122

Reid CA et al. HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.
Br. J. Pharmacol., 2012 Jan , 165 (49-56).

124

Kusch J et al. How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels.
Nat. Chem. Biol., 2012 Feb , 8 (162-9).

126

Schweikart K et al. The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity.
Toxicol In Vitro, 2012 Dec 20 , 27 (745-751).

127

Orio P et al. Role of Ih in the firing pattern of mammalian cold thermoreceptor endings.
J. Neurophysiol., 2012 Dec , 108 (3009-23).

128

Chen Y et al. Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents.
Alcohol. Clin. Exp. Res., 2012 Dec , 36 (2036-46).

130

132

Hofmann F et al. Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.
Cardiovasc. Res., 2012 Aug 1 , 95 (317-26).

133

Monticone S et al. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.
J. Clin. Endocrinol. Metab., 2012 Aug , 97 (E1567-72).

137

Della Santina L et al. Processing of retinal signals in normal and HCN deficient mice.
PLoS ONE, 2012 , 7 (e29812).

144

Emery EC et al. HCN2 ion channels play a central role in inflammatory and neuropathic pain.
Science, 2011 Sep 9 , 333 (1462-6).

145

Kraemer WP et al. Vibrational energies of LiH2(+) and LiD2(+) in the Ã1Σ+ electronic state.
J Phys Chem A, 2011 Oct 20 , 115 (11313-20).

151

Horwitz GC et al. HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function.
J. Neurosci., 2011 Nov 16 , 31 (16814-25).

160

Herrmann S et al. Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
J. Mol. Cell. Cardiol., 2011 Dec , 51 (997-1006).

161

Klöckner U et al. Differential reduction of HCN channel activity by various types of lipopolysaccharide.
J. Mol. Cell. Cardiol., 2011 Aug , 51 (226-35).

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Xu X et al. Structural basis for the cAMP-dependent gating in the human HCN4 channel.
J. Biol. Chem., 2010 Nov 19 , 285 (37082-91).

172

Lin YC et al. Inactivation of L-type calcium channel modulated by HCN2 channel.
Am. J. Physiol., Cell Physiol., 2010 May , 298 (C1029-37).

173

Hegle AP et al. Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.
Am. J. Physiol., Cell Physiol., 2010 May , 298 (C1066-76).

175

Gardarin A et al. Endoplasmic reticulum is a major target of cadmium toxicity in yeast.
Mol. Microbiol., 2010 May , 76 (1034-48).

177

Baruscotti M et al. HCN-related channelopathies.
Pflugers Arch., 2010 Jul , 460 (405-15).

181

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Ma J et al. Use of rats mesenchymal stem cells modified with mHCN2 gene to create biologic pacemakers.
J. Huazhong Univ. Sci. Technol. Med. Sci., 2010 Aug , 30 (447-52).

184

Dibbens LM et al. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes.
Ann. Neurol., 2010 Apr , 67 (542-6).

186

Zhang J et al. Cardiac stem cells differentiate into sinus node-like cells.
Tohoku J. Exp. Med., 2010 , 222 (113-20).

187

Yu HG et al. Non-proteolytic HCN2 in the heart.
J. Biol. Chem., 2009 Sep 25 , 284 (le7; author reply le8).

192

Gassanov N et al. Distinct regulation of cardiac I(f) current via thyroid receptors alpha1 and beta1.
Pflugers Arch., 2009 Oct , 458 (1061-8).

195

Valiunas V et al. Coupling an HCN2-expressing cell to a myocyte creates a two-cell pacing unit.
J. Physiol. (Lond.), 2009 Nov 1 , 587 (5211-26).

197

Schweizer PA et al. Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.
Basic Res. Cardiol., 2009 May 7 , ().

199

Zhang Q et al. Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Biochim. Biophys. Acta, 2009 May , 1788 (1138-47).

200

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Alig J et al. Control of heart rate by cAMP sensitivity of HCN channels.
Proc. Natl. Acad. Sci. U.S.A., 2009 Jul 21 , 106 (12189-94).

208

Brandt MC et al. Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties.
Am. J. Physiol. Heart Circ. Physiol., 2009 Jul , 297 (H355-63).

211

Chen X et al. Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice.
J. Neurophysiol., 2009 Jan , 101 (129-40).

216

Nair AV et al. Movements of native C505 during channel gating in CNGA1 channels.
Eur. Biophys. J., 2009 Apr , 38 (465-78).

219

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Li HX et al. [The changes of funny currents in the ventricular myocytes of neonatal rats and adult rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2008 Nov , 24 (411-5).

225

Craven KB et al. C-terminal movement during gating in cyclic nucleotide-modulated channels.
J. Biol. Chem., 2008 May 23 , 283 (14728-38).

230

Hardel N et al. Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.
Cardiovasc. Res., 2008 Jul 1 , 79 (52-60).

236

Momin A et al. Role of the hyperpolarization-activated current Ih in somatosensory neurons.
J. Physiol. (Lond.), 2008 Dec 15 , 586 (5911-29).

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Stillitano F et al. Molecular basis of funny current (If) in normal and failing human heart.
J. Mol. Cell. Cardiol., 2008 Aug , 45 (289-99).

239

Vemana S et al. Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.
Am. J. Physiol., Cell Physiol., 2008 Aug , 295 (C557-65).

244

Huang X et al. Age-related down-regulation of HCN channels in rat sinoatrial node.
Basic Res. Cardiol., 2007 Sep , 102 (429-35).

248

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Muto T et al. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes.
Am. J. Physiol. Heart Circ. Physiol., 2007 Nov , 293 (H2710-8).

253

Liu J et al. Organisation of the mouse sinoatrial node: structure and expression of HCN channels.
Cardiovasc. Res., 2007 Mar 1 , 73 (729-38).

255

Yu X et al. Calcium influx through If channels in rat ventricular myocytes.
Am. J. Physiol., Cell Physiol., 2007 Mar , 292 (C1147-55).

256

El-Kholy W et al. Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.
Mol. Endocrinol., 2007 Mar , 21 (753-64).

258

Herrmann S et al. Pathophysiology of HCN channels.
Pflugers Arch., 2007 Jul , 454 (517-22).

267

Boyes J et al. Functional presynaptic HCN channels in the rat globus pallidus.
Eur. J. Neurosci., 2007 Apr , 25 (2081-92).

269

Varghese A et al. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.
Prog. Biophys. Mol. Biol., 2006 Jan-Apr , 90 (26-37).

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Elinder F et al. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.
J. Physiol. (Lond.), 2006 Sep 1 , 575 (417-31).

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Dekker JP et al. Cooperative gating between single HCN pacemaker channels.
J. Gen. Physiol., 2006 Nov , 128 (561-7).

284

Fernández-Velasco M et al. I K1 and I f in ventricular myocytes isolated from control and hypertrophied rat hearts.
Pflugers Arch., 2006 May , 452 (146-54).

287

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Aponte Y et al. Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus.
J. Physiol. (Lond.), 2006 Jul 1 , 574 (229-43).

294

Kuisle M et al. Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.
J. Physiol. (Lond.), 2006 Aug 15 , 575 (83-100).

299

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Bajorat R et al. Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages.
J. Neurosci. Res., 2005 Oct 15 , 82 (206-13).

303

Stieber J et al. Functional expression of the human HCN3 channel.
J. Biol. Chem., 2005 Oct 14 , 280 (34635-43).

305

Ma YN et al. [Association between familial febrile convulsions and HCN2 gene]
Zhonghua Yi Xue Za Zhi, 2005 Mar 16 , 85 (663-6).

311

van Welie I et al. Low affinity block of native and cloned hyperpolarization-activated Ih channels by Ba2+ ions.
Eur. J. Pharmacol., 2005 Jan 10 , 507 (15-20).

312

Johnson JP et al. The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.
Proc. Natl. Acad. Sci. U.S.A., 2005 Feb 22 , 102 (2742-7).

317

Galindo BE et al. A new hyperpolarization-activated, cyclic nucleotide-gated channel from sea urchin sperm flagella.
Biochem. Biophys. Res. Commun., 2005 Aug 19 , 334 (96-101).

321

Gravante B et al. Interaction of the pacemaker channel HCN1 with filamin A.
J. Biol. Chem., 2004 Oct 15 , 279 (43847-53).

322

Qu J et al. MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes.
J. Biol. Chem., 2004 Oct 15 , 279 (43497-502).

323

Rosen MR et al. Recreating the biological pacemaker.
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331

Strauss U et al. An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.
Eur. J. Neurosci., 2004 Jun , 19 (3048-58).

332

Koch U et al. Distribution of HCN1 and HCN2 in rat auditory brainstem nuclei.
Eur. J. Neurosci., 2004 Jul , 20 (79-91).

334

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Stieber J et al. Pacemaker channels and sinus node arrhythmia.
Trends Cardiovasc. Med., 2004 Jan , 14 (23-8).

337

Heubach JF et al. Electrophysiological properties of human mesenchymal stem cells.
J. Physiol. (Lond.), 2004 Feb 1 , 554 (659-72).

338

Craven KB et al. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
J. Gen. Physiol., 2004 Dec , 124 (663-77).

339

Notomi T et al. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
J. Comp. Neurol., 2004 Apr 5 , 471 (241-76).

342

Potapova I et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers.
Circ. Res., 2004 Apr 16 , 94 (952-9).

345

Stieber J et al. Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.
J. Biol. Chem., 2003 Sep 5 , 278 (33672-80).

346

Zagotta WN et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels.
Nature, 2003 Sep 11 , 425 (200-5).

349

Pál B et al. HCN channels contribute to the intrinsic activity of cochlear pyramidal cells.
Cell. Mol. Life Sci., 2003 Oct , 60 (2189-99).

350

Qu J et al. Expression and function of a biological pacemaker in canine heart.
Circulation, 2003 Mar 4 , 107 (1106-9).

351

Azene EM et al. Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.
J. Physiol. (Lond.), 2003 Mar 1 , 547 (349-56).

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Macri V et al. Separable gating mechanisms in a Mammalian pacemaker channel.
J. Biol. Chem., 2002 Sep 27 , 277 (35939-46).

364

Bonilla M et al. Essential role of calcineurin in response to endoplasmic reticulum stress.
EMBO J., 2002 May 15 , 21 (2343-53).

368

Proenza C et al. Pacemaker channels produce an instantaneous current.
J. Biol. Chem., 2002 Feb 15 , 277 (5101-9).

371

Qu J et al. Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.
Pflugers Arch., 2002 Aug , 444 (597-601).

372

Greenwood IA et al. Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells.
Am. J. Physiol., Cell Physiol., 2002 Apr , 282 (C744-53).

373

Sauviat MP et al. [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]
J. Soc. Biol., 2002 , 196 (339-48).

374

Chen J et al. The S4-S5 linker couples voltage sensing and activation of pacemaker channels.
Proc. Natl. Acad. Sci. U.S.A., 2001 Sep 25 , 98 (11277-82).

378

Zong X et al. A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.
J. Biol. Chem., 2001 Mar 2 , 276 (6313-9).

379

Ulens C et al. Functional heteromerization of HCN1 and HCN2 pacemaker channels.
J. Biol. Chem., 2001 Mar 2 , 276 (6069-72).

380

Yasui K et al. I(f) current and spontaneous activity in mouse embryonic ventricular myocytes.
Circ. Res., 2001 Mar 16 , 88 (536-42).

382

Wainger BJ et al. Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Nature, 2001 Jun 14 , 411 (805-10).

383

Altomare C et al. Integrated allosteric model of voltage gating of HCN channels.
J. Gen. Physiol., 2001 Jun , 117 (519-32).

390

Monteggia LM et al. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.
Brain Res. Mol. Brain Res., 2000 Sep 30 , 81 (129-39).

391

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Moroni A et al. Kinetic and ionic properties of the human HCN2 pacemaker channel.
Pflugers Arch., 2000 Mar , 439 (618-26).

394

Gögelein H et al. Inhibition of IKs channels by HMR 1556.
Naunyn Schmiedebergs Arch. Pharmacol., 2000 Dec , 362 (480-8).

395

Vaca L et al. Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
FEBS Lett., 2000 Aug 11 , 479 (35-40).

398

Moosmang S et al. Differential distribution of four hyperpolarization-activated cation channels in mouse brain.
Biol. Chem., 1999 Jul-Aug , 380 (975-80).

399

Vaccari T et al. The human gene coding for HCN2, a pacemaker channel of the heart.
Biochim. Biophys. Acta, 1999 Sep 3 , 1446 (419-25).

405

Ludwig A et al. A family of hyperpolarization-activated mammalian cation channels.
Nature, 1998 Jun 11 , 393 (587-91).