Channelpedia

HCN1 Channel

379 automatically matched literature references

4

Huang X et al. Age-associated expression of HCN channel isoforms in rat sinoatrial node.
Exp. Biol. Med. (Maywood), 2015 Sep 3 , ().

6

Goldstein PA HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore.
Anesth. Analg., 2015 Sep , 121 (594-6).

10

Li N et al. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1219-27).

12

O'Donnell AM et al. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
World J. Gastroenterol., 2015 May 14 , 21 (5635-40).

17

21

Husse B et al. Generation of cardiac pacemaker cells by programming and differentiation.
Biochim. Biophys. Acta, 2015 Dec 8 , ().

25

Kopp-Scheinpflug C et al. Nitric oxide selectively suppresses IH currents mediated by HCN1-containing channels.
J. Physiol. (Lond.), 2015 Apr 1 , 593 (1685-700).

26

DiFrancesco JC et al. Dysfunctional HCN ion channels in neurological diseases.
Front Cell Neurosci, 2015 , 6 (174).

27

Fürst O et al. Isoform dependent regulation of human HCN channels by cholesterol.
Sci Rep, 2015 , 5 (14270).

28

Herrmann S et al. HCN channels--modulators of cardiac and neuronal excitability.
Int J Mol Sci, 2015 , 16 (1429-47).

30

Günther A et al. Distinct expression patterns of HCN channels in HL-1 cardiomyocytes.
BMC Cell Biol., 2015 , 16 (18).

33

35

Yang YC et al. Dexmedetomidine produced analgesic effect via inhibition of HCN currents.
Eur. J. Pharmacol., 2014 Oct 5 , 740 (560-4).

37

Li J et al. [Inhibition of HCN1 channels by ketamine accounts for its antidepressant actions].
Sichuan Da Xue Xue Bao Yi Xue Ban, 2014 Nov , 45 (888-92, 932).

39

41

Nava C et al. De novo mutations in HCN1 cause early infantile epileptic encephalopathy.
Nat. Genet., 2014 Jun , 46 (640-5).

43

Shah MM Cortical HCN channels: function, trafficking and plasticity.
J. Physiol. (Lond.), 2014 Jul 1 , 592 (2711-9).

46

He C et al. Neurophysiology of HCN channels: From cellular functions to multiple regulations.
Prog. Neurobiol., 2014 Jan , 112 (1-23).

47

Stadler K et al. Elevation in Type I Interferons Inhibits HCN1 and Slows Cortical Neuronal Oscillations.
Cereb. Cortex, 2014 Jan , 24 (199-210).

54

63

Akbor MM et al. Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice.
Biochem. Biophys. Res. Commun., 2013 Nov 8 , 441 (25-30).

66

Du L et al. The role of HCN channels within the periaqueductal gray in neuropathic pain.
Brain Res., 2013 Mar 15 , 1500 (36-44).

69

71

Benarroch EE HCN channels: function and clinical implications.
Neurology, 2013 Jan 15 , 80 (304-10).

73

Fenske S et al. Sick Sinus Syndrome in HCN1-Deficient Mice.
Circulation, 2013 Dec 17 , 128 (2585-94).

74

Stillitano F et al. Chronic atrial fibrillation alters the functional properties of If in the human atrium.
J. Cardiovasc. Electrophysiol., 2013 Dec , 24 (1391-400).

78

Zhou C et al. Forebrain HCN1 channels contribute to hypnotic actions of ketamine.
Anesthesiology, 2013 Apr , 118 (785-95).

84

Shah MM HCN1 channels: a new therapeutic target for depressive disorders?
Sci Signal, 2012 Oct 2 , 5 (pe44).

85

Huang Z et al. TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
J. Neurosci., 2012 Oct 17 , 32 (14835-48).

100

103

Reid CA et al. HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.
Br. J. Pharmacol., 2012 Jan , 165 (49-56).

104

107

Orio P et al. Role of Ih in the firing pattern of mammalian cold thermoreceptor endings.
J. Neurophysiol., 2012 Dec , 108 (3009-23).

109

110

Hofmann F et al. Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.
Cardiovasc. Res., 2012 Aug 1 , 95 (317-26).

112

Tanimoto N et al. HCN1 channels significantly shape retinal photoresponses.
Adv. Exp. Med. Biol., 2012 , 723 (807-12).

113

Scicchitano P et al. HCN channels and heart rate.
Molecules, 2012 , 17 (4225-35).

115

Della Santina L et al. Processing of retinal signals in normal and HCN deficient mice.
PLoS ONE, 2012 , 7 (e29812).

116

Speranza L et al. The biological effects of ivabradine in cardiovascular disease.
Molecules, 2012 , 17 (4924-35).

122

McClure KJ et al. Discovery of a novel series of selective HCN1 blockers.
Bioorg. Med. Chem. Lett., 2011 Sep 15 , 21 (5197-201).

124

Popova NV et al. Association of adaptor protein TRIP8b with clathrin.
J. Neurochem., 2011 Sep , 118 (988-98).

129

Giocomo LM et al. Grid cells use HCN1 channels for spatial scaling.
Cell, 2011 Nov 23 , 147 (1159-70).

130

Hussaini SA et al. Increased size and stability of CA1 and CA3 place fields in HCN1 knockout mice.
Neuron, 2011 Nov 17 , 72 (643-53).

131

Horwitz GC et al. HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function.
J. Neurosci., 2011 Nov 16 , 31 (16814-25).

144

Herrmann S et al. Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
J. Mol. Cell. Cardiol., 2011 Dec , 51 (997-1006).

151

154

Hegle AP et al. Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.
Am. J. Physiol., Cell Physiol., 2010 May , 298 (C1066-76).

158

Wierschke S et al. Hyperpolarization-activated cation currents in human epileptogenic neocortex.
Epilepsia, 2010 Mar , 51 (404-14).

160

Hablitz JJ et al. Abnormal pyramidal cell morphology and HCN channel expression in cortical dysplasia.
Epilepsia, 2010 Jul , 51 Suppl 3 (52-5).

161

Baruscotti M et al. HCN-related channelopathies.
Pflugers Arch., 2010 Jul , 460 (405-15).

163

Baruscotti M et al. The cardiac pacemaker current.
J. Mol. Cell. Cardiol., 2010 Jan , 48 (55-64).

170

174

Huang Z et al. Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis.
J. Neurosci., 2009 Sep 2 , 29 (10979-88).

175

Arimitsu T et al. Activity-dependent regulation of HCN1 protein in cortical neurons.
Biochem. Biophys. Res. Commun., 2009 Sep 11 , 387 (87-91).

180

Chan YC et al. Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels.
Pflugers Arch., 2009 Nov , 459 (25-38).

182

Schweizer PA et al. Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.
Basic Res. Cardiol., 2009 May 7 , ().

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185

Zhang Q et al. Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Biochim. Biophys. Acta, 2009 May , 1788 (1138-47).

187

194

Brandt MC et al. Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties.
Am. J. Physiol. Heart Circ. Physiol., 2009 Jul , 297 (H355-63).

195

Biel M et al. Hyperpolarization-activated cation channels: from genes to function.
Physiol. Rev., 2009 Jul , 89 (847-85).

199

Chen X et al. HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine.
J. Neurosci., 2009 Jan 21 , 29 (600-9).

200

Chen X et al. Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice.
J. Neurophysiol., 2009 Jan , 101 (129-40).

201

Maher MP et al. HCN channels as targets for drug discovery.
Comb. Chem. High Throughput Screen., 2009 Jan , 12 (64-72).

203

Wahl-Schott C et al. HCN channels: structure, cellular regulation and physiological function.
Cell. Mol. Life Sci., 2009 Feb , 66 (470-94).

204

Massella A et al. Gabapentin treatment improves motor coordination in a mice model of progressive ataxia.
Brain Res., 2009 Dec 8 , 1301 (135-42).

206

Atkinson SE et al. Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons.
J. Neurophysiol., 2009 Aug , 102 (735-51).

208

Demontis GC et al. Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors.
Invest. Ophthalmol. Vis. Sci., 2009 Apr , 50 (1948-55).

209

Wickenden AD et al. HCN pacemaker channels and pain: a drug discovery perspective.
Curr. Pharm. Des., 2009 , 15 (2149-68).

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216

Li HX et al. [The changes of funny currents in the ventricular myocytes of neonatal rats and adult rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2008 Nov , 24 (411-5).

218

Blumenfeld H et al. Early treatment suppresses the development of spike-wave epilepsy in a rat model.
Epilepsia, 2008 Mar , 49 (400-9).

226

Momin A et al. Role of the hyperpolarization-activated current Ih in somatosensory neurons.
J. Physiol. (Lond.), 2008 Dec 15 , 586 (5911-29).

228

Stillitano F et al. Molecular basis of funny current (If) in normal and failing human heart.
J. Mol. Cell. Cardiol., 2008 Aug , 45 (289-99).

229

Vemana S et al. Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.
Am. J. Physiol., Cell Physiol., 2008 Aug , 295 (C557-65).

236

Huang X et al. Age-related down-regulation of HCN channels in rat sinoatrial node.
Basic Res. Cardiol., 2007 Sep , 102 (429-35).

240

242

Muto T et al. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes.
Am. J. Physiol. Heart Circ. Physiol., 2007 Nov , 293 (H2710-8).

245

Liu J et al. Organisation of the mouse sinoatrial node: structure and expression of HCN channels.
Cardiovasc. Res., 2007 Mar 1 , 73 (729-38).

247

El-Kholy W et al. Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.
Mol. Endocrinol., 2007 Mar , 21 (753-64).

248

Hattori K et al. Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.
Mol. Genet. Metab., 2007 Jul , 91 (285-93).

249

Herrmann S et al. Pathophysiology of HCN channels.
Pflugers Arch., 2007 Jul , 454 (517-22).

255

Ishii TM et al. Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.
Biochem. Biophys. Res. Commun., 2007 Aug 3 , 359 (592-8).

261

Boyes J et al. Functional presynaptic HCN channels in the rat globus pallidus.
Eur. J. Neurosci., 2007 Apr , 25 (2081-92).

262

Bois P et al. Molecular regulation and pharmacology of pacemaker channels.
Curr. Pharm. Des., 2007 , 13 (2338-49).

263

Ivanova E et al. Retinal bipolar cell types differ in their inventory of ion channels.
Vis. Neurosci., 2006 Mar-Apr , 23 (143-54).

266

Elinder F et al. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.
J. Physiol. (Lond.), 2006 Sep 1 , 575 (417-31).

270

Prole DL et al. Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.
J. Gen. Physiol., 2006 Sep , 128 (273-82).

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Aponte Y et al. Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus.
J. Physiol. (Lond.), 2006 Jul 1 , 574 (229-43).

277

Kuisle M et al. Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.
J. Physiol. (Lond.), 2006 Aug 15 , 575 (83-100).

279

Milligan CJ et al. HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata.
Brain Res., 2006 Apr 7 , 1081 (79-91).

280

Bucchi A et al. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.
J. Physiol. (Lond.), 2006 Apr 15 , 572 (335-46).

281

Yu X et al. Effect of non-specific HCN1 blocker CsCl on spatial learning and memory in mouse.
J. Huazhong Univ. Sci. Technol. Med. Sci., 2006 , 26 (164-6).

282

Siu CW et al. HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering.
J. Membr. Biol., 2006 , 214 (115-22).

288

Bajorat R et al. Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages.
J. Neurosci. Res., 2005 Oct 15 , 82 (206-13).

289

Stieber J et al. Functional expression of the human HCN3 channel.
J. Biol. Chem., 2005 Oct 14 , 280 (34635-43).

298

van Welie I et al. Low affinity block of native and cloned hyperpolarization-activated Ih channels by Ba2+ ions.
Eur. J. Pharmacol., 2005 Jan 10 , 507 (15-20).

299

Marionneau C et al. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.
J. Physiol. (Lond.), 2005 Jan 1 , 562 (223-34).

300

Azene EM et al. Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation.
Biochem. Biophys. Res. Commun., 2005 Feb 25 , 327 (1131-42).

303

Galindo BE et al. A new hyperpolarization-activated, cyclic nucleotide-gated channel from sea urchin sperm flagella.
Biochem. Biophys. Res. Commun., 2005 Aug 19 , 334 (96-101).

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309

Gravante B et al. Interaction of the pacemaker channel HCN1 with filamin A.
J. Biol. Chem., 2004 Oct 15 , 279 (43847-53).

311

Gill CH et al. Characterization of the human HCN1 channel and its inhibition by capsazepine.
Br. J. Pharmacol., 2004 Oct , 143 (411-21).

314

319

Strauss U et al. An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.
Eur. J. Neurosci., 2004 Jun , 19 (3048-58).

320

Koch U et al. Distribution of HCN1 and HCN2 in rat auditory brainstem nuclei.
Eur. J. Neurosci., 2004 Jul , 20 (79-91).

322

323

Vemana S et al. S4 movement in a mammalian HCN channel.
J. Gen. Physiol., 2004 Jan , 123 (21-32).

327

Notomi T et al. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
J. Comp. Neurol., 2004 Apr 5 , 471 (241-76).

333

Pál B et al. HCN channels contribute to the intrinsic activity of cochlear pyramidal cells.
Cell. Mol. Life Sci., 2003 Oct , 60 (2189-99).

337

Azene EM et al. Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.
J. Physiol. (Lond.), 2003 Mar 1 , 547 (349-56).

339

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342

Sui T et al. [NMR study on solution configuration of mHCN1 pore peptide]
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao, 2003 Jan , 35 (59-63).

343

Chaplan SR et al. Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
J. Neurosci., 2003 Feb 15 , 23 (1169-78).

351

Lorincz A et al. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites.
Nat. Neurosci., 2002 Nov , 5 (1185-93).

355

Biel M et al. Cardiac HCN channels: structure, function, and modulation.
Trends Cardiovasc. Med., 2002 Jul , 12 (206-12).

356

Chen J et al. Voltage sensing and activation gating of HCN pacemaker channels.
Trends Cardiovasc. Med., 2002 Jan , 12 (42-5).

358

Greenwood IA et al. Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells.
Am. J. Physiol., Cell Physiol., 2002 Apr , 282 (C744-53).

361

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Ishii TM et al. Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels.
J. Physiol. (Lond.), 2001 Nov 15 , 537 (93-100).

364

Ulens C et al. Functional heteromerization of HCN1 and HCN2 pacemaker channels.
J. Biol. Chem., 2001 Mar 2 , 276 (6069-72).

366

Wainger BJ et al. Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Nature, 2001 Jun 14 , 411 (805-10).

367

Altomare C et al. Integrated allosteric model of voltage gating of HCN channels.
J. Gen. Physiol., 2001 Jun , 117 (519-32).

373

Monteggia LM et al. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.
Brain Res. Mol. Brain Res., 2000 Sep 30 , 81 (129-39).

377

Moosmang S et al. Differential distribution of four hyperpolarization-activated cation channels in mouse brain.
Biol. Chem., 1999 Jul-Aug , 380 (975-80).