Channelpedia

Kir3.1 Channel

459 automatically matched literature references

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Ehrich JM et al. Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons.
J. Neurosci., 2015 Sep 16 , 35 (12917-31).

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Bukiya AN et al. Cholesterol increases the open probability of cardiac KACh currents.
Biochim. Biophys. Acta, 2015 Oct , 1848 (2406-13).

15

Amaral AC et al. Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex.
Neuroscience, 2015 Feb 12 , 286 (79-86).

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24

Raphemot R et al. Direct activation of β-cell KATP channels with a novel xanthine derivative.
Mol. Pharmacol., 2014 Jun , 85 (858-65).

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32

Farhy Tselnicker I et al. Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.
Proc. Natl. Acad. Sci. U.S.A., 2014 Apr 1 , 111 (5018-23).

33

Treuer AV et al. NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy.
Int J Physiol Pathophysiol Pharmacol, 2014 , 6 (37-46).

34

Kumar M et al. Focus on Kir7.1: physiology and channelopathy.
Channels (Austin), 2014 , 8 (488-95).

35

Ramos-Hunter SJ et al. Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.
Bioorg. Med. Chem. Lett., 2013 Sep 15 , 23 (5195-8).

39

Zylbergold P et al. A novel, radiolabel-free pulse chase strategy to study Kir3 channel ontogeny.
J. Recept. Signal Transduct. Res., 2013 Jun , 33 (144-52).

41

Ravens U et al. Atrial selectivity of antiarrhythmic drugs.
J. Physiol. (Lond.), 2013 Jul 16 , ().

43

Richard-Lalonde M et al. Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.
Mol. Pharmacol., 2013 Feb , 83 (416-28).

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Holmegard HN et al. Genetic variation in the parasympathetic signaling pathway in patients with reflex syncope.
Genet. Mol. Res., 2013 , 12 (2601-10).

59

Wydeven N et al. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
Proc. Natl. Acad. Sci. U.S.A., 2012 Dec 26 , 109 (21492-7).

62

Caro LN et al. Engineering of an artificial light-modulated potassium channel.
PLoS ONE, 2012 , 7 (e43766).

63

Lü Q et al. Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.
Mol Med Report, 2011 Sep-Oct , 4 (941-5).

67

Chen PC et al. Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.
Am. J. Physiol., Cell Physiol., 2011 Mar , 300 (C506-16).

68

Wu Y et al. GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat.
J. Neurophysiol., 2011 Jun , 105 (2715-28).

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Jo HY et al. Kir3.1 channel is functionally involved in TLR4-mediated signaling.
Biochem. Biophys. Res. Commun., 2011 Apr 22 , 407 (687-91).

76

Arora D et al. Altered neurotransmission in the mesolimbic reward system of Girk mice.
J. Neurochem., 2010 Sep 1 , 114 (1487-97).

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Walsh KB A real-time screening assay for GIRK1/4 channel blockers.
J Biomol Screen, 2010 Dec , 15 (1229-37).

92

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Stansfeld PJ et al. PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.
Biochemistry, 2009 Nov 24 , 48 (10926-33).

96

Ishihara K et al. Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Biochem. Biophys. Res. Commun., 2009 Mar 20 , 380 (832-7).

106

Robitaille M et al. Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes.
Cell. Signal., 2009 Apr , 21 (488-501).

110

Saenz del Burgo L et al. Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.
J. Comp. Neurol., 2008 Oct 20 , 510 (581-606).

114

Perry CA et al. Predisposition to late-onset obesity in GIRK4 knockout mice.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jun 10 , 105 (8148-53).

115

Pravetoni M et al. Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.
Genes Brain Behav., 2008 Jul , 7 (523-31).

117

Park HJ et al. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.
J. Clin. Invest., 2008 Jan , 118 (259-71).

119

Robertson JL et al. Long-pore electrostatics in inward-rectifier potassium channels.
J. Gen. Physiol., 2008 Dec , 132 (613-32).

120

Brevet M et al. Expression of K+ channels in normal and cancerous human breast.
Histol. Histopathol., 2008 Aug , 23 (965-72).

121

Ehrlich JR Inward rectifier potassium currents as a target for atrial fibrillation therapy.
J. Cardiovasc. Pharmacol., 2008 Aug , 52 (129-35).

126

Lopes CM et al. Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels.
Channels (Austin), 2007 Mar-Apr , 1 (124-34).

127

Inanobe A et al. Structural diversity in the cytoplasmic region of G protein-gated inward rectifier K+ channels.
Channels (Austin), 2007 Jan-Feb , 1 (39-45).

128

Nishida M et al. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera.
EMBO J., 2007 Sep 5 , 26 (4005-15).

130

Lucarini N et al. Genetic polymorphisms and idiopathic generalized epilepsies.
Pediatr. Neurol., 2007 Sep , 37 (157-64).

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Calloe K et al. Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.
Biochem. Biophys. Res. Commun., 2007 Dec 28 , 364 (889-95).

141

Kawano T et al. Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels.
Mol. Pharmacol., 2007 Apr , 71 (1179-84).

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Steinecker B et al. The GIRK1 brain variant GIRK1d and its functional impact on heteromultimeric GIRK channels.
J. Recept. Signal Transduct. Res., 2007 , 27 (369-82).

146

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine.
J. Pharmacol. Sci., 2006 Nov , 102 (278-87).

148

Thomas AM et al. Differential phosphoinositide binding to components of the G protein-gated K+ channel.
J. Membr. Biol., 2006 May , 211 (43-53).

149

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil.
Neuropsychopharmacology, 2006 Mar , 31 (516-24).

155

Hüttmann K et al. Molecular and functional properties of neurons in the human lateral amygdala.
Mol. Cell. Neurosci., 2006 Feb , 31 (210-7).

156

Felix JP et al. Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.
Biochemistry, 2006 Aug 22 , 45 (10129-39).

158

Olsen ML et al. Functional expression of Kir4.1 channels in spinal cord astrocytes.
Glia, 2006 Apr 1 , 53 (516-28).

161

Kanjhan R et al. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner.
J. Pharmacol. Exp. Ther., 2005 Sep , 314 (1353-61).

169

Marionneau C et al. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.
J. Physiol. (Lond.), 2005 Jan 1 , 562 (223-34).

171

Koyrakh L et al. Molecular and cellular diversity of neuronal G-protein-gated potassium channels.
J. Neurosci., 2005 Dec 7 , 25 (11468-78).

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Koike-Tani M et al. Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel.
J. Physiol. (Lond.), 2005 Apr 15 , 564 (489-500).

183

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Neuropsychopharmacology, 2004 Oct , 29 (1841-51).

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Nikolov EN et al. Coordination of membrane excitability through a GIRK1 signaling complex in the atria.
J. Biol. Chem., 2004 May 28 , 279 (23630-6).

189

Pil J et al. Synthesis and electrophysiological characterization of cyclic morphiceptin analogues.
Biochem. Pharmacol., 2004 May 15 , 67 (1887-95).

196

Leaney JL et al. Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.
Am. J. Physiol., Cell Physiol., 2004 Jul , 287 (C182-91).

197

Mao J et al. Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
Proc. Natl. Acad. Sci. U.S.A., 2004 Jan 27 , 101 (1087-92).

200

Wellner-Kienitz MC et al. Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh).
J. Physiol. (Lond.), 2004 Dec 1 , 561 (459-69).

201

Zhang YY et al. Carboxy-terminal determinants of conductance in inward-rectifier K channels.
J. Gen. Physiol., 2004 Dec , 124 (729-39).

204

Chen L et al. Inwardly rectifying potassium channels in rat retinal ganglion cells.
Eur. J. Neurosci., 2004 Aug , 20 (956-64).

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Borlak J et al. Hallmarks of ion channel gene expression in end-stage heart failure.
FASEB J., 2003 Sep , 17 (1592-608).

208

John SA et al. Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2.
J. Physiol. (Lond.), 2003 Oct 1 , 552 (23-34).

211

Zhao Q et al. Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.
Mol. Pharmacol., 2003 Nov , 64 (1085-91).

212

Benians A et al. Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels.
Proc. Natl. Acad. Sci. U.S.A., 2003 May 13 , 100 (6239-44).

213

Kourrich S et al. Inwardly rectifying Kir3.1 subunit knockdown impairs learning and memory in an olfactory associative task in rat.
Brain Res. Mol. Brain Res., 2003 May 12 , 113 (97-106).

215

Pil J et al. Serine 329 of the mu-opioid receptor interacts differently with agonists.
J. Pharmacol. Exp. Ther., 2003 Mar , 304 (924-30).

217

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).
Br. J. Pharmacol., 2003 Mar , 138 (1119-28).

218

Trapp S et al. Identification of residues contributing to the ATP binding site of Kir6.2.
EMBO J., 2003 Jun 16 , 22 (2903-12).

220

Takano M et al. Regulation of cardiac inwardly rectifying potassium channels by membrane lipid metabolism.
Prog. Biophys. Mol. Biol., 2003 Jan , 81 (67-79).

221

Mao J et al. Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis.
J. Biol. Chem., 2003 Feb 28 , 278 (7091-8).

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Leach RN et al. Expression, purification and spectroscopic studies of full-length Kir3.1 channel C-terminus.
Biochim. Biophys. Acta, 2003 Dec 1 , 1652 (83-90).

227

Murasaki O et al. Site of action of the general anesthetic propofol in muscarinic M1 receptor-mediated signal transduction.
J. Pharmacol. Exp. Ther., 2003 Dec , 307 (995-1000).

232

Hoang QV et al. Effects of orexin (hypocretin) on GIRK channels.
J. Neurophysiol., 2003 Aug , 90 (693-702).

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Kobayashi T et al. Functional characterization of an endogenous Xenopus oocyte adenosine receptor.
Br. J. Pharmacol., 2002 Jan , 135 (313-22).

242

Wickman K et al. Structural characterization of the mouse Girk genes.
Gene, 2002 Feb 6 , 284 (241-50).

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Bettahi I et al. Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh.
J. Biol. Chem., 2002 Dec 13 , 277 (48282-8).

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Leaney JL et al. A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits.
J. Biol. Chem., 2002 Aug 9 , 277 (28803-9).

253

Sadja R et al. Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.
Proc. Natl. Acad. Sci. U.S.A., 2002 Aug 6 , 99 (10783-8).

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Dobrzynski H et al. Effects of ACh and adenosine mediated by Kir3.1 and Kir3.4 on ferret ventricular cells.
Am. J. Physiol. Heart Circ. Physiol., 2002 Aug , 283 (H615-30).

263

Zhou W et al. Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels.
Proc. Natl. Acad. Sci. U.S.A., 2001 May 22 , 98 (6482-7).

267

Shui Z et al. Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+ channels.
Am. J. Physiol. Heart Circ. Physiol., 2001 Jun , 280 (H2554-62).

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Tong XY et al. [The expression levels of GIRK1 and IRK1 in memory deficit rats]
Yao Xue Xue Bao, 2001 Jul , 36 (485-8).

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Medina I et al. A switch mechanism for G beta gamma activation of I(KACh).
J. Biol. Chem., 2000 Sep 22 , 275 (29709-16).

288

Mark MD et al. G-protein mediated gating of inward-rectifier K+ channels.
Eur. J. Biochem., 2000 Oct , 267 (5830-6).

294

Yakubovich D et al. Slow modal gating of single G protein-activated K+ channels expressed in Xenopus oocytes.
J. Physiol. (Lond.), 2000 May 1 , 524 Pt 3 (737-55).

298

Bloms-Funke P et al. Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor.
Peptides, 2000 Jul , 21 (1141-6).

303

Bradley KK et al. Kir3.1/3.2 encodes an I(KACh)-like current in gastrointestinal myocytes.
Am. J. Physiol. Gastrointest. Liver Physiol., 2000 Feb , 278 (G289-96).

307

Keren-Raifman T et al. Expression cloning of KCRF, a potassium channel regulatory factor.
Biochem. Biophys. Res. Commun., 2000 Aug 11 , 274 (852-8).

308

Wickman K et al. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4.
J. Neurosci., 2000 Aug 1 , 20 (5608-15).

311

Jin W et al. Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.
Biochemistry, 1999 Oct 26 , 38 (14294-301).

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Ho IH et al. Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels.
J. Physiol. (Lond.), 1999 Nov 1 , 520 Pt 3 (645-51).

321

Otero AS et al. Wild-type NM23-H1, but not its S120 mutants, suppresses desensitization of muscarinic potassium current.
Biochim. Biophys. Acta, 1999 Mar 8 , 1449 (157-68).

322

Ho IH et al. Molecular determinants for sodium-dependent activation of G protein-gated K+ channels.
J. Biol. Chem., 1999 Mar 26 , 274 (8639-48).

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Fernández-Fernández JM et al. Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones.
J. Physiol. (Lond.), 1999 Mar 15 , 515 ( Pt 3) (631-7).

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Ulens C et al. The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands.
Eur. J. Pharmacol., 1999 Dec 3 , 385 (239-45).

333

Rohács T et al. Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides.
J. Biol. Chem., 1999 Dec 17 , 274 (36065-72).

335

Kobayashi T et al. Ethanol opens G-protein-activated inwardly rectifying K+ channels.
Nat. Neurosci., 1999 Dec , 2 (1091-7).

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Saitoh O et al. RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents.
J. Biol. Chem., 1999 Apr 2 , 274 (9899-904).

343

Jin W et al. A novel high-affinity inhibitor for inward-rectifier K+ channels.
Biochemistry, 1998 Sep 22 , 37 (13291-9).

348

Krapivinsky G et al. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation.
J. Biol. Chem., 1998 Jul 3 , 273 (16946-52).

349

Luchian T et al. Ion permeation through a G-protein activated (GIRK1/GIRK5) inwardly rectifying potassium channel.
Biochim. Biophys. Acta, 1998 Jan 19 , 1368 (167-70).

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Sun L et al. Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors.
J. Pharmacol. Exp. Ther., 1998 Feb , 284 (625-32).

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Ruiz-Velasco V et al. Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons.
J. Physiol. (Lond.), 1998 Dec 15 , 513 ( Pt 3) (761-73).

357

Kuzhikandathil EV et al. Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines.
Mol. Cell. Neurosci., 1998 Dec , 12 (390-402).

358

Ivanova-Nikolova TT et al. Muscarinic K+ channel in the heart. Modal regulation by G protein beta gamma subunits.
J. Gen. Physiol., 1998 Aug , 112 (199-210).

367

Wickman K et al. Partial structure, chromosome localization, and expression of the mouse Girk4 gene.
Genomics, 1997 Mar 15 , 40 (395-401).

370

Nelson CS et al. Cloning and characterization of Kir3.1 (GIRK1) C-terminal alternative splice variants.
Brain Res. Mol. Brain Res., 1997 Jun , 46 (185-96).

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Isomoto S et al. Inwardly rectifying potassium channels: their molecular heterogeneity and function.
Jpn. J. Physiol., 1997 Feb , 47 (11-39).

383

Woodward R et al. Molecular determinants for assembly of G-protein-activated inwardly rectifying K+ channels.
J. Biol. Chem., 1997 Apr 18 , 272 (10823-30).

386

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Wischmeyer E et al. Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels.
Mol. Cell. Neurosci., 1997 , 9 (194-206).

394

Silverman SK et al. Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel.
J. Biol. Chem., 1996 Nov 29 , 271 (30524-8).

397

Sui JL et al. Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism.
J. Gen. Physiol., 1996 Nov , 108 (381-91).

399

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Chan KW et al. A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins.
J. Gen. Physiol., 1996 Mar , 107 (381-97).

404

Navarro B et al. Nonselective and G betagamma-insensitive weaver K+ channels.
Science, 1996 Jun 28 , 272 (1950-3).

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Schoots O et al. Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum.
Brain Res. Mol. Brain Res., 1996 Jul , 39 (23-30).

412

Nelson CS et al. Melatonin receptors activate heteromeric G-protein coupled Kir3 channels.
Neuroreport, 1996 Feb 29 , 7 (717-20).

418

Schreibmayer W et al. Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
Nature, 1996 Apr 18 , 380 (624-7).

422

Dixon AK et al. Distribution of mRNA encoding the inwardly rectifying K+ channel, BIR1 in rat tissues.
FEBS Lett., 1995 Oct 23 , 374 (135-40).

430

Ikeda K et al. Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.
Biochem. Biophys. Res. Commun., 1995 Mar 8 , 208 (302-8).

435

Philipson LH et al. Functional expression of an epitope-tagged G protein-coupled K+ channel (GIRK1).
J. Biol. Chem., 1995 Jun 16 , 270 (14604-10).

437

Inanobe A et al. G beta gamma directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1.
Biochem. Biophys. Res. Commun., 1995 Jul 26 , 212 (1022-8).

440

Doupnik CA et al. Intrinsic gating properties of a cloned G protein-activated inward rectifier K+ channel.
J. Gen. Physiol., 1995 Jul , 106 (1-23).

441

Kovoor A et al. Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1).
J. Biol. Chem., 1995 Jan 13 , 270 (589-95).

443

Krapivinsky G et al. G beta gamma binds directly to the G protein-gated K+ channel, IKACh.
J. Biol. Chem., 1995 Dec 8 , 270 (29059-62).

444

Inanobe A et al. Immunological and physical characterization of the brain G protein-gated muscarinic potassium channel.
Biochem. Biophys. Res. Commun., 1995 Dec 26 , 217 (1238-44).

445

Lesage F et al. Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.
J. Biol. Chem., 1995 Dec 1 , 270 (28660-7).

452

Yano H et al. Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA.
Mol. Pharmacol., 1994 May , 45 (854-60).

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Makhina EN et al. Cloning and expression of a novel human brain inward rectifier potassium channel.
J. Biol. Chem., 1994 Aug 12 , 269 (20468-74).