Kv12.3

Description: potassium voltage-gated channel, subfamily H (eag-related), member 4
Gene: Kcnh4
Alias: Kv12.3

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Introduction

Kv12.3 (also known as BEC2; ELK1), encoded by the gene KCNH4, is a sodium, voltage-gated, type I, alpha subunit channel. Kv12.3 is is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.

Experimental data

Rat Kv12.3 gene in CHO host cells datasheet
Click for details 15 °C show 104 cells	Click for details 25 °C show 73 cells	Click for details 35 °C show 208 cells

Mouse Kv12.3 gene in CHO host cells datasheet
	Click for details 25 °C show 64 cells	Click for details 35 °C show 176 cells
Human Kv12.3 gene in CHO host cells datasheet
	Click for details 25 °C show 68 cells	Click for details 35 °C show 133 cells

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Gene

Kv10-12 phylogenetic tree
Phylogenetic tree for the Kv10–12 families. [606]

Species	NCBI gene ID	Chromosome	Position
Human	23415	17	24251
Mouse	380728	11	19737
Rat	114032	10	19834

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Transcript

Species	NCBI accession	Length (nt)
Human	NM_012285.3	3788
Mouse	NM_001081194.2	3784
Rat	NM_053630.2	3746

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Protein Isoforms

Species	Uniprot ID	Length (aa)
Human	Q9UQ05	1017
Mouse	A2A5F7	1018
Rat	Q9R1T9	1017

Isoforms

Transcript

Length (nt)

Protein

Length (aa)

Variant

Isoform

Known

NM_001081194.2

3784

NP_001074663.1

1018

Predicted

XM_006533646.4

3918

XP_006533709.1

763

transcript variant X1

isoform X1

XM_036156819.1

2865

XP_036012712.1

653

transcript variant X2

isoform X2

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Post-Translational Modifications

PTM

Position

Type

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Structure

Visual Representation of Kv12.3 Structure
Methodology for visual representation of structure available here

There are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C terminus, respectively. [606]

Kv12.3 predicted AlphaFold size

Species	Area (Å²)	Reference
Human	7753.35	source
Mouse	7534.22	source
Rat	5946.38	source

Methodology for AlphaFold size prediction and disclaimer are available here

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Kinetics

Kv12.3 is a slowly activating voltage-gated potassium channel with threshold for activation at 90 mV [809].

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Expression and Distribution

Kv12.3 was identified in the brain (telencephalon),[809], [810] neuroblastoma, esophagus, oligodendroglioma, lung, primary B-cell neoplasia, cerebellum, pituitary gland [795].

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Function

Angiogenesis

ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP [1760]

Ovarian Cancer influenced by Angiogenesis

MiR-378 was overexpressed in ovarian cancer cells and tumors vs. normal ovarian epithelial cells. Overexpressing miR-378 in ovarian cancer cells altered expression of genes associated with angiogenesis (ALCAM, EHD1, ELK3, TLN1), apoptosis (RPN2, HIPK3), and cell cycle regulation (SWAP-70, LSM14A, RDX) [1761]

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Interaction

Ba2+

Ba2+ blocks Kv12.3. [809]

KCNH8

Coexpression of KCNH8 with dominant-negative KCNH8, KCNH3, and KCNH4 subunits led to suppression of the KCNH8 currents, suggesting that Elk channels can form heteromultimers. [808]

pH

Kv10.2, Kv12.2, and Kv12.3 are similarly modulated by external pH. Thus high pH sensitivity has now been observed for six of eight mammalian EAG superfamily orthologues, including all members of the Eag and Elk gene families. The Erg family channels Kv11.2 and Kv11.3 have not yet been examined for pH sensitivity, but they also have the EAG-specific acidic residues [1832]