Channelpedia

[Expression of Eag1 K(+) channel in prostate cancer and its significance].


Authors: Yi-Qun Zheng, Zhi-Jian Li, Xin Gao, Xiao-Bin Zhang, Fa-Jiang Li, Ying-Jiang Shi, Gang Luo, Wei Li

Journal, date & volume: Zhonghua Nan Ke Xue, 2013 Mar , 19, 205-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23700723

Channelpedia reference in: Kv10.1

Abstract
To investigate the expression of the Eag1 K( +) channel in the prostate cancer (PCa) tissue, its correlation with the development and progression of PCa, and whether it could be a target for the diagnosis and treatment of PCa.We used RT-PCR and immunohistochemistry to determine the mRNA and protein expressions of the Eag1 K(+) channel in the normal peritumoral tissue of androgen-dependent PCa (ADPCa) (group A) and androgen-independent PCa (AIPCa) (group B) as well as in the tumorous tissue of ADPCa (group C) and AIPCa (group D).The relative coefficients of the mRNA expression of the Eag1 K(+) channel were 0.265 +/- 0.413, 0.167 +/- 0.511, 2.673 +/- 2.988 and 2.815 +/- 2.901 in groups A, B, C and D, respectively, increased significantly in the latter two groups (P < 0.05). The positive rates of the protein expression of the Eag1 K (+) channel were significantly higher in groups C (88.9%) and D (86.7%) than in A (7.4%) and B (6.7%) (P < 0.05).The Eag1 K(+) channel might be involved in the pathophysiological processes of PCa, and is expected to be a valuable target for the diagnosis and treatment of PCa.