Channelpedia

Ca

Description: Calcium channel

Edit

Introduction

Catterall, 2000). Voltage-gated calcium channels (VGCCs), heteromultimeric protein complexes consisting of an alpha1 sub- unit, as well as ancillary beta, alpha2-delta, and possibly gamma subunits (Hofmann et al., 1994), are a primary route through which calcium can enter cells. The alpha1 subunit forms the ion conducting pore and contains the ion selectivity filter and voltage sensors which gate the channel in response to changes in membrane potential (Hofmann et al., 1994). Auxiliary beta and alpha2-delta subunits modulate channel kinetics and targeting of the alpha1 subunit to the membrane (Neely et al., 1993; Tareilus et al., 1997; Yasuda et al., 2004). VGCCs are encoded by 10 genes, four of which encode the L-type calcium channel family and include Cav1.1, Cav1.2, Cav1.3 and Cav1.4 (Ertel et al., 2000). These channels are highly sensitive to 1,4- dihydropyridines, phenylalkylamines and benzothiazepines, display slow inactivation kinetics, and have a high voltage activating threshold (Tsien et al., 1987; Catterall, 2000). (From Peloquin [232], upload of papers in due course)


Experimental data


Edit

Gene


Edit

Transcript


Edit

Ontology


Edit

Interaction


Edit

Protein


Edit

Structure


Edit

Distribution


Edit

Expression


Edit

Functional


Edit

Kinetics


Edit

Model

[1] Generic Ca (Model ID = 8)

Animalrat
CellType Neocortical L5PC
Age 0 Days
Temperature35.0°C
Reversal 50.0 mV
Ion Ca +
Ligand ion
Reference I Reuveni et. al; J. Neurosci. 1993 Nov
mpower 2.0
mAlpha (0.055*(-27-v))/(exp((-27-v)/3.8) - 1) If v neq -27
mBeta (0.94*exp((-75-v)/17))
hpower 1.0
hAlpha (0.000457*exp((-13-v)/50))
hBeta (0.0065/(exp((-v-15)/28)+1))
49

MOD - xml - channelML

[2] Ca_LVA (Model ID = 46)

Animalrat
CellType Hippocampal CA3 PC
Age 0 Days
Temperature34.0°C
Reversal 131.04 mV
Ion Ca +
Ligand ion
Reference R B Avery et. al; J. Neurosci. 1996 Sep 15
mpower 2.0
mInf 1.0000/(1+ exp((v - -30.000)/-6))
mTau (5.0000 + 20.0000/(1+exp((v - -25.000)/5)))/qt
hpower 1.0
hInf 1.0000/(1+ exp((v - -80.000)/6.4))
hTau (20.0000 + 50.0000/(1+exp((v - -40.000)/7)))/qt
190


References


Edit

Credits

Contributors: Rajnish Ranjan

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/190/ , accessed on [date]