Channelpedia

TRPM8 Channel

362 automatically matched literature references

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McEntire DM et al. Pain transduction: a pharmacologic perspective.
Expert Rev Clin Pharmacol, 2016 May 23 , (1-12).

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Ghosh D et al. Journey of a cold sensor - VAMP7-dependent transport of TRPM8.
Channels (Austin), 2016 May 2 , (1-3).

8

Liu Z et al. TRPM8: a potential target for cancer treatment.
J. Cancer Res. Clin. Oncol., 2016 Jan 23 , ().

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Yudin Y et al. Phospholipase C δ4regulates cold sensitivity in mice.
J. Physiol. (Lond.), 2016 Apr 8 , ().

17

Yee NS TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer.
Adv Protein Chem Struct Biol, 2016 , 104 (127-55).

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da Silva Serra I et al. Characterization of cutaneous and articular sensory neurons.
Mol Pain, 2016 , 12 ().

20

Liu SC et al. Identification of the cold receptor TRPM8 in the nasal mucosa.
Am J Rhinol Allergy, 2015 Jul-Aug , 29 (e112-6).

22

Carrasquel-Ursulaez W et al. Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8.
Temperature (Austin), 2015 Apr-Jun , 2 (188-200).

24

Dai Y TRPs and pain.
Semin Immunopathol, 2015 Sep 15 , ().

25

Wei ZL et al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.
Bioorg. Med. Chem. Lett., 2015 Sep 15 , 25 (4011-5).

27

Billeter AT et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response.
Surgery, 2015 Sep , 158 (646-54).

30

Sidaway P Urinary incontinence: TRPM8 influences bladder filling.
Nat Rev Urol, 2015 Sep , 12 (476).

32

Yu X et al. TRP channel functions in the gastrointestinal tract.
Semin Immunopathol, 2015 Oct 12 , ().

33

Patel R et al. Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera.
Eur. J. Neurosci., 2015 Oct 10 , ().

34

Bidaux G et al. Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel.
Biophys. J., 2015 Nov 3 , 109 (1840-51).

36

Qin DM et al. [Role of transient receptor potential melastatin 8 channels in migraine mechanism in rats].
Zhongguo Dang Dai Er Ke Za Zhi, 2015 May , 17 (515-9).

37

Tokuda M et al. Dentin and pulp sense cold stimulus.
Med. Hypotheses, 2015 May , 84 (442-4).

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Yu X et al. TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Mar 15 , 308 (G489-96).

43

De Petrocellis L et al. Structure-activity relationships of the prototypical TRPM8 agonist icilin.
Bioorg. Med. Chem. Lett., 2015 Jun 1 , 25 (2285-90).

44

Benemei S et al. TRP channels.
Curr Opin Pharmacol, 2015 Jun , 22 (18-23).

46

Asuthkar S et al. TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells.
Oncotarget, 2015 Jul 10 , 6 (17221-36).

53

Palkar R et al. The molecular and cellular basis of thermosensation in mammals.
Curr. Opin. Neurobiol., 2015 Jan 23 , 34C (14-19).

54

Toro CA et al. Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.
J. Neurosci., 2015 Jan 14 , 35 (571-82).

55

Yrbas ML et al. Pharmacological mechanism underlying the antinociceptive activity of vanillic acid.
Pharmacol. Biochem. Behav., 2015 Feb 21 , 132 (88-95).

57

Khajavi N et al. Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells.
Cell. Signal., 2015 Feb , 27 (315-25).

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Alptekin M et al. Gene expressions of TRP channels in glioblastoma multiforme and relation with survival.
Tumour Biol., 2015 Dec , 36 (9209-13).

61

Andrews MD et al. Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.
ACS Med Chem Lett, 2015 Apr 9 , 6 (419-24).

71

Belmonte C et al. What Causes Eye Pain?
Curr Ophthalmol Rep, 2015 , 3 (111-121).

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Lötsch J et al. Multimodal distribution of human cold pain thresholds.
PLoS ONE, 2015 , 10 (e0125822).

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Mueller-Tribbensee SM et al. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
PLoS ONE, 2015 , 10 (e0128242).

81

Quallo T et al. TRPM8 is a neuronal osmosensor that regulates eye blinking in mice.
Nat Commun, 2015 , 6 (7150).

87

Bron R et al. Piezo2 expression in corneal afferent neurons.
J. Comp. Neurol., 2014 Sep 1 , 522 (2967-79).

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Egbuniwe O et al. TRPA1 and TRPV4 activation in human odontoblasts stimulates ATP release.
J. Dent. Res., 2014 Sep , 93 (911-7).

91

Gardiner JC et al. The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist.
Eur. J. Pharmacol., 2014 Oct 5 , 740 (398-409).

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Winchester WJ et al. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.
J. Pharmacol. Exp. Ther., 2014 Nov , 351 (259-69).

101

Franken J et al. TRP channels in lower urinary tract dysfunction.
Br. J. Pharmacol., 2014 May , 171 (2537-51).

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Teliban A et al. Responses of intact and injured sural nerve fibers to cooling and menthol.
J. Neurophysiol., 2014 May , 111 (2071-83).

117

Teichert RW et al. Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass.
Proc. Natl. Acad. Sci. U.S.A., 2014 Jan 27 , ().

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Gohlke BO et al. SuperPain--a resource on pain-relieving compounds targeting ion channels.
Nucleic Acids Res., 2014 Jan 1 , 42 (D1107-12).

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Amato A et al. Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation.
Eur. J. Pharmacol., 2014 Dec 15 , 745 (129-34).

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Ortar G et al. Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.
Bioorg. Med. Chem. Lett., 2014 Dec 1 , 24 (5507-11).

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Suzuki H et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor.
Am. J. Physiol., Cell Physiol., 2014 Aug 15 , 307 (C384-94).

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Hosoya T et al. TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice.
Neurogastroenterol. Motil., 2014 Aug , 26 (1112-21).

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Patel R et al. Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats.
J. Pharmacol. Exp. Ther., 2014 Apr , 349 (47-55).

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Steinberg X et al. A structural view of ligand-dependent activation in thermoTRP channels.
Front Physiol, 2014 , 5 (171).

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Almaraz L et al. TRPM8.
Handb Exp Pharmacol, 2014 , 222 (547-79).

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Ramos-Filho AC et al. Menthol inhibits detrusor contractility independently of TRPM8 activation.
PLoS ONE, 2014 , 9 (e111616).

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Cohen MR et al. Structure of thermally activated TRP channels.
Curr Top Membr, 2014 , 74 (181-211).

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Baez D et al. Gating of thermally activated channels.
Curr Top Membr, 2014 , 74 (51-87).

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Roper SD TRPs in taste and chemesthesis.
Handb Exp Pharmacol, 2014 , 223 (827-71).

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Lucaciu OC et al. Itch sensation through transient receptor potential channels: a systematic review and relevance to manual therapy.
J Manipulative Physiol Ther, 2013 Jul-Aug , 36 (385-93).

166

Brederson JD et al. Targeting TRP channels for pain relief.
Eur. J. Pharmacol., 2013 Sep 15 , 716 (61-76).

167

Li Q et al. Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation.
Int. J. Mol. Med., 2013 Sep , 32 (637-46).

169

Park B et al. Cooling the Skin: Understanding a Specific Cutaneous Thermosensation.
J Lifestyle Med, 2013 Sep , 3 (91-7).

170

Julius D TRP Channels and Pain.
Annu. Rev. Cell Dev. Biol., 2013 Oct 6 , 29 (355-384).

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Vetter I et al. Amplified cold transduction in native nociceptors by M-channel inhibition.
J. Neurosci., 2013 Oct 16 , 33 (16627-41).

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Ortar G et al. 3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
Bioorg. Med. Chem. Lett., 2013 Oct 15 , 23 (5614-8).

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Grace MS et al. Transient Receptor Potential (TRP) channels in the airway: role in airway disease.
Br. J. Pharmacol., 2013 Nov 28 , ().

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Sisignano M et al. TRP-channels as key integrators of lipid pathways in nociceptive neurons.
Prog. Lipid Res., 2013 Nov 25 , 53C (93-107).

178

Brown A et al. Serendipity in drug-discovery: a new series of 2-(benzyloxy)benzamides as TRPM8 antagonists.
Bioorg. Med. Chem. Lett., 2013 Nov 15 , 23 (6118-22).

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Rios ER et al. TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate.
Chem. Biol. Interact., 2013 May 25 , 203 (573-9).

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Pogorzala LA et al. The cellular code for mammalian thermosensation.
J. Neurosci., 2013 Mar 27 , 33 (5533-41).

199

Park S et al. Cold exposure lowers energy expenditure at the cellular level.
Cell Biol. Int., 2013 Jun , 37 (638-42).

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McCoy DD et al. Enhanced insulin clearance in mice lacking TRPM8 channels.
Am. J. Physiol. Endocrinol. Metab., 2013 Jul , 305 (E78-88).

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Vahabi B et al. TRPM8 agonists modulate contraction of the pig urinary bladder.
Can. J. Physiol. Pharmacol., 2013 Jul , 91 (503-9).

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Li L et al. Differential inhibition of the TRPM8 ion channel by Gαq and Gα 11.
Channels (Austin), 2013 Jan 18 , 7 ().

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Farco JA et al. Menthol - pharmacology of an important naturally medicinal "cool".
Mini Rev Med Chem, 2013 Jan 1 , 13 (124-31).

214

Schulze A et al. Apomorphine is a bimodal modulator of TRPA1 channels.
Mol. Pharmacol., 2013 Feb , 83 (542-51).

216

Shapovalov G et al. Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8.
Cell Rep, 2013 Aug 15 , 4 (504-15).

217

Shabir S et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
Am. J. Physiol. Renal Physiol., 2013 Aug 1 , 305 (F396-406).

218

Ramachandran R et al. TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Proc. Natl. Acad. Sci. U.S.A., 2013 Apr 30 , 110 (7476-81).

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Matsushita A et al. Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve.
Biochem. Biophys. Res. Commun., 2013 Apr 26 , 434 (179-84).

222

Zhu B et al. Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Bioorg. Med. Chem. Lett., 2013 Apr 1 , 23 (2234-7).

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Leanza L et al. Intracellular ion channels and cancer.
Front Physiol, 2013 , 4 (227).

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Tang Z et al. Pirt functions as an endogenous regulator of TRPM8.
Nat Commun, 2013 , 4 (2179).

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Liu XR et al. Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats.
Cell. Physiol. Biochem., 2013 , 31 (892-904).

234

Tsumura M et al. Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts.
PLoS ONE, 2013 , 8 (e82233).

237

Ferrer-Montiel A et al. Advances in modulating thermosensory TRP channels.
Expert Opin Ther Pat, 2012 Sep , 22 (999-1017).

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Guo H et al. Role of TRPM in melanocytes and melanoma.
Exp. Dermatol., 2012 Sep , 21 (650-4).

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Jang Y et al. Quantitative analysis of TRP channel genes in mouse organs.
Arch. Pharm. Res., 2012 Oct , 35 (1823-30).

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Wang Y et al. Menthol inhibits the proliferation and motility of prostate cancer DU145 cells.
Pathol. Oncol. Res., 2012 Oct , 18 (903-10).

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Ortar G et al. Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Bioorg. Med. Chem. Lett., 2012 May 15 , 22 (3535-9).

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Preti D et al. TRP channels as therapeutic targets in airway disorders: a patent review.
Expert Opin Ther Pat, 2012 Jun , 22 (663-95).

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Schürks M Genetics of migraine in the age of genome-wide association studies.
J Headache Pain, 2012 Jan , 13 (1-9).

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Premkumar LS et al. TRP channels and analgesia.
Life Sci., 2012 Aug 14 , ().

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Yudin Y et al. Regulation of TRPM8 channel activity.
Mol. Cell. Endocrinol., 2012 Apr 28 , 353 (68-74).

275

Shailendra Kapoor MD TRPM8 antagonists and their emerging role in the modulation of pain and allodynia.
Biochem. Biophys. Res. Commun., 2012 Apr 20 , 420 (937).

276

Bharate SS et al. Modulation of thermoreceptor TRPM8 by cooling compounds.
ACS Chem Neurosci, 2012 Apr 18 , 3 (248-67).

278

Yang Z et al. Effect of surgical castration on expression of TRPM8 in urogenital tract of male rats.
Mol. Biol. Rep., 2012 Apr , 39 (4797-802).

280

Sherkheli MA et al. Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3.
ScientificWorldJournal, 2012 , 2012 (982725).

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Gkika D et al. TRP channels in prostate cancer: the good, the bad and the ugly?
Asian J. Androl., 2011 Sep , 13 (673-6).

299

Janssens A et al. Ligand stoichiometry of the cold- and menthol-activated channel TRPM8.
J. Physiol. (Lond.), 2011 Oct 15 , 589 (4827-35).

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Pedretti A et al. Exploring the activation mechanism of TRPM8 channel by targeted MD simulations.
Biochem. Biophys. Res. Commun., 2011 Oct 14 , 414 (14-9).

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Alenmyr L et al. TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.
Clin Physiol Funct Imaging, 2011 Nov , 31 (435-44).

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Kim SH et al. Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner.
Biochem. Biophys. Res. Commun., 2011 Mar 4 , 406 (30-5).

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Banner KH et al. TRP channels: Emerging targets for respiratory disease.
, 2011 Mar 17 , ().

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Kim HY et al. Characterization of Dental Nociceptive Neurons.
, 2011 Mar 1 , ().

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Vincent F et al. TRPV4 Agonists and Antagonists.
, 2011 Jun 14 , ().

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Defalco J et al. TRPM8 Biology and Medicinal Chemistry.
, 2011 Jun 14 , ().

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Martínez-López P et al. TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
J. Cell. Physiol., 2011 Jun , 226 (1620-31).

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Mälkiä A et al. The emerging pharmacology of TRPM8 channels: hidden therapeutic potential underneath a cold surface.
Curr Pharm Biotechnol, 2011 Jan 1 , 12 (54-67).

330

[Effect of TRPM8 ion channel activation on thermoregulatory response to cooling].
Ross Fiziol Zh Im I M Sechenova, 2011 Feb , 97 (218-26).

333

Zhong J et al. Umbellulone modulates TRP channels.
Pflugers Arch., 2011 Dec , 462 (861-70).

335

Frasnelli J et al. Perception of specific trigeminal chemosensory agonists.
Neuroscience, 2011 Aug 25 , 189 (377-83).

338

Latorre R et al. A cool channel in cold transduction.
Physiology (Bethesda), 2011 Aug , 26 (273-85).

340

Harrington AM et al. A novel role for TRPM8 in visceral afferent function.
, 2011 Apr 11 , ().

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Wetsel WC Sensing hot and cold with TRP channels.
Int J Hyperthermia, 2011 , 27 (388-98).

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Zholos A et al. TRPM channels in the vasculature.
Adv. Exp. Med. Biol., 2011 , 704 (707-29).

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Chung MK et al. Role of TRP channels in pain sensation.
Adv. Exp. Med. Biol., 2011 , 704 (615-36).

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Harteneck C et al. Synthetic modulators of TRP channel activity.
Adv. Exp. Med. Biol., 2011 , 704 (87-106).

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Nieto-Posadas A et al. TRP channel gating physiology.
Curr Top Med Chem, 2011 , 11 (2131-50).

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Baylie RL et al. Inhibition of the cardiac L-type calcium channel current by the TRPM8 agonist, (-)-menthol.
J. Physiol. Pharmacol., 2010 Oct , 61 (543-50).

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