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Nav2.2

Synonyms: nav2.2

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Introduction

Nav2.2 ( also known as Scn7A, Na-G) is expressed in astrocytes of rat CNS.

The mammalian sodium channel isoforms that have been identified thus far can be subdivided into three main groups. The type 1 channels (Nav1.x) share significant sequence similarity with each other,4 and all but one have been functionally expressed in exogenous systems. The type 2 channels (Nav2.x) are approximately 50% identical to the type 1 channels, with significant differences in regions that are critical for channel function. [873] None of these channels have been expressed in an exogenous system before 1999, so that it was not possible to draw any conclusions about the properties of these channels before 1999. [881]


Experimental data


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Gene

Scn7A may represent the same gene as Scn6A, since only one full-length cDNA has been isolated for these two genes from any single species. [880]

Gene bank access is M96578 under its original name Na-G [882], and Y09164 under its original name SCL11 [879]. [881]

The phylogenetic relationship of mammalian voltage-gated sodium channel alpha subunit genes, including Scn7A can be found at [880].


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Transcript


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Ontology


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Interaction


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Protein


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Structure

See figure 1 in Goldin 2000 [878] for a transmembrane folding diagram displaying the structure of a generic voltage gated sodium alpha subunit.


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Distribution


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Expression

In the rat brain, Nav2.2 can be found in astrocytes and PNS (DRG). [881]


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Functional


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Kinetics


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Model


References

878

Goldin AL et al. Nomenclature of voltage-gated sodium channels.
Neuron, 2000 Nov , 28 (365-8).

880

Plummer NW et al. Evolution and diversity of mammalian sodium channel genes.
Genomics, 1999 Apr 15 , 57 (323-31).

881

Goldin AL Diversity of mammalian voltage-gated sodium channels.
Ann. N. Y. Acad. Sci., 1999 Apr 30 , 868 (38-50).

879

Akopian AN et al. Structure and distribution of a broadly expressed atypical sodium channel.
FEBS Lett., 1997 Jan 3 , 400 (183-7).

882

Gautron S et al. The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression.
Proc. Natl. Acad. Sci. U.S.A., 1992 Aug 1 , 89 (7272-6).


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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/130/ , accessed on [date]