Channelpedia

Nav1.6 Channel

309 automatically matched literature references

6

Makinson CD et al. An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.
Exp. Neurol., 2016 Jan , 275 Pt 1 (46-58).

12

13

Olson HE et al. Mutations in epilepsy and intellectual disability genes in patients with features of Rett syndrome.
Am. J. Med. Genet. A, 2015 Sep , 167A (2017-25).

14

Liu C et al. Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.
J. Biol. Chem., 2015 May 8 , 290 (12048-57).

16

Mercimek-Mahmutoglu S et al. Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Epilepsia, 2015 May , 56 (707-16).

19

20

Igci YZ et al. Expression profiling of SCN8A and NDUFC2 genes in colorectal carcinoma.
Exp. Oncol., 2015 Mar , 37 (77-80).

26

Wang M et al. [Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Zhonghua Yi Xue Za Zhi, 2015 Jan 6 , 95 (61-5).

28

Wagnon JL et al. Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.
Hum. Mol. Genet., 2015 Jan 15 , 24 (506-15).

30

Sato T et al. Glial reaction in the spinal cord of the degenerating muscle mouse (Scn8a (dmu)).
Neurochem. Res., 2015 Jan , 40 (124-9).

32

Larsen J et al. The phenotypic spectrum of SCN8A encephalopathy.
Neurology, 2015 Feb 3 , 84 (480-9).

35

Huang X et al. Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node.
Mech. Ageing Dev., 2015 Dec , 152 (80-90).

54

Zerem A et al. Paternal germline mosaicism of a SCN2A mutation results in Ohtahara syndrome in half siblings.
Eur. J. Paediatr. Neurol., 2014 Sep , 18 (567-71).

56

de Kovel CG et al. Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy.
Epilepsy Res., 2014 Nov , 108 (1511-8).

59

Gilchrist J et al. Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
ACS Chem. Biol., 2014 May 16 , 9 (1204-12).

60

Zhang YY et al. Characterization of functional ion channels in human cardiac c-kit+ progenitor cells.
Basic Res. Cardiol., 2014 May , 109 (407).

61

Thériault O et al. Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate.
Eur. J. Pharmacol., 2014 Mar 15 , 727 (158-66).

63

Black JA et al. Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus.
Exp. Neurol., 2014 Mar , 253 (174-9).

64

Ohba C et al. Early onset epileptic encephalopathy caused by de novo SCN8A mutations.
Epilepsia, 2014 Jul , 55 (994-1000).

67

Sawyer NT et al. Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress.
Psychoneuroendocrinology, 2014 Jan , 39 (225-36).

68

Jones JM et al. Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.
Genesis, 2014 Feb , 52 (141-8).

70

Bouafia A et al. Axonal expression of sodium channels and neuropathology of the plaques in multiple sclerosis.
Neuropathol. Appl. Neurobiol., 2014 Aug , 40 (579-90).

71

Makinson CD et al. Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Neurobiol. Dis., 2014 Aug , 68 (16-25).

72

Brauner JM et al. Risperidone inhibits voltage-gated sodium channels.
Eur. J. Pharmacol., 2014 Apr 5 , 728 (100-6).

76

Zimmer T et al. Voltage-gated sodium channels in the mammalian heart.
Glob Cardiol Sci Pract, 2014 , 2014 (449-63).

77

[To the mechanisms of antiarrhythmic action of Allapinine].
Bioorg. Khim., 2013 Jan-Feb , 39 (105-16).

79

Xiao M et al. FGF14 localization and organization of the axon initial segment.
Mol. Cell. Neurosci., 2013 Sep , 56 (393-403).

82

Black JA et al. Noncanonical roles of voltage-gated sodium channels.
Neuron, 2013 Oct 16 , 80 (280-91).

85

87

Driscoll HE et al. Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability.
J. Neurosci., 2013 Jun 5 , 33 (9644-54).

90

Sun W et al. Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.
J. Physiol. (Lond.), 2013 Jan 1 , 591 (241-55).

91

Stevens M et al. Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.
J. Neuroimmunol., 2013 Aug 15 , 261 (21-8).

92

Kaufmann SG et al. Distribution and function of sodium channel subtypes in human atrial myocardium.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (133-41).

103

Oliva M et al. Sodium channels and the neurobiology of epilepsy.
Epilepsia, 2012 Nov , 53 (1849-59).

105

112

Liu P et al. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.
J. Neurophysiol., 2012 Jun , 107 (3155-67).

117

O'Brien JE et al. Rbfox proteins regulate alternative splicing of neuronal sodium channel SCN8A.
Mol. Cell. Neurosci., 2012 Feb , 49 (120-6).

124

Smith BJ et al. Reduced Retinal Function in the Absence of Na(v)1.6.
PLoS ONE, 2012 , 7 (e31476).

127

Black JA et al. Sodium channels and microglial function.
, 2011 Oct 1 , ().

134

Widmark J et al. Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes.
Mol. Biol. Evol., 2011 Jan , 28 (859-71).

137

Ho C et al. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons.
Mol. Cell. Neurosci., 2011 Jan , 46 (159-66).

139

Reimer MM et al. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion.
J. Neurosci., 2011 Dec 7 , 31 (18185-94).

141

Zhao J et al. Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits.
J. Neurophysiol., 2011 Aug , 106 (608-19).

147

Wright MA et al. In vivo evidence for transdifferentiation of peripheral neurons.
Development, 2010 Sep , 137 (3047-56).

149

Lorincz A et al. Molecular identity of dendritic voltage-gated sodium channels.
Science, 2010 May 14 , 328 (906-9).

151

152

Meisler MH et al. Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects.
J. Physiol. (Lond.), 2010 Jun 1 , 588 (1841-8).

153

Catterall WA et al. NaV1.1 channels and epilepsy.
J. Physiol. (Lond.), 2010 Jun 1 , 588 (1849-59).

154

Moreno RL et al. Developmental regulation of subtype-specific motor neuron excitability.
Ann. N. Y. Acad. Sci., 2010 Jun , 1198 (201-7).

160

Osorio N et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
J. Physiol. (Lond.), 2010 Feb 15 , 588 (651-70).

163

Gasser A et al. Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
J. Biol. Chem., 2010 Aug 20 , 285 (26149-61).

167

Chen K et al. Cerebellum-related characteristics of Scn8a-mutant mice.
Cerebellum, 2009 Sep , 8 (192-201).

169

170

Wang JA et al. Membrane trauma and Na+ leak from Nav1.6 channels.
Am. J. Physiol., Cell Physiol., 2009 Oct , 297 (C823-34).

175

Sharkey LM et al. Evaluation of SCN8A as a candidate gene for autosomal dominant essential tremor.
Parkinsonism Relat. Disord., 2009 May , 15 (321-3).

176

Zhu HL et al. Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes.
Naunyn Schmiedebergs Arch. Pharmacol., 2009 May , 379 (453-60).

178

Carrithers MD et al. Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A.
J. Biol. Chem., 2009 Mar 20 , 284 (8114-26).

179

Blumenfeld H et al. Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis.
Epilepsia, 2009 Jan , 50 (44-55).

180

Shakkottai VG et al. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.
Neurobiol. Dis., 2009 Jan , 33 (81-8).

184

Black JA et al. Sodium channel activity modulates multiple functions in microglia.
Glia, 2009 Aug 1 , 57 (1072-81).

190

Duflocq A et al. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments.
Mol. Cell. Neurosci., 2008 Oct , 39 (180-92).

191

192

Howell VM et al. A targeted deleterious allele of the splicing factor SCNM1 in the mouse.
Genetics, 2008 Nov , 180 (1419-27).

193

Blumenfeld H et al. Early treatment suppresses the development of spike-wave epilepsy in a rat model.
Epilepsia, 2008 Mar , 49 (400-9).

194

Chen YH et al. Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities.
J. Biomed. Sci., 2008 Jan , 15 (69-78).

196

Lorincz A et al. Cell-type-dependent molecular composition of the axon initial segment.
J. Neurosci., 2008 Dec 31 , 28 (14329-40).

197

Wang Y et al. SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population.
Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008 Dec 12 , 32 (1902-4).

199

McKinney BC et al. Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).
Genes Brain Behav., 2008 Aug , 7 (629-38).

200

201

Kaneko Y et al. Expression of Nav1.1 in rat retinal AII amacrine cells.
Neurosci. Lett., 2007 Sep 7 , 424 (83-8).

202

Buczek O et al. Structure and sodium channel activity of an excitatory I1-superfamily conotoxin.
Biochemistry, 2007 Sep 4 , 46 (9929-40).

203

Black JA et al. Sodium channel expression within chronic multiple sclerosis plaques.
J. Neuropathol. Exp. Neurol., 2007 Sep , 66 (828-37).

207

Martínez-Gómez A et al. Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.
Neuroreport, 2007 Mar 26 , 18 (447-50).

210

Huang X et al. [Expression and function of voltage-gated Na+ channel isoforms in rat sinoatrial node]
Nan Fang Yi Ke Da Xue Xue Bao, 2007 Jan , 27 (52-5).

211

214

Enomoto A et al. Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice.
J. Neurophysiol., 2007 Aug , 98 (710-9).

217

Shirahata E et al. Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.
J. Neurophysiol., 2006 Sep , 96 (1347-57).

218

Pineda RH et al. Knockdown of Nav1.6a Na+ channels affects zebrafish motoneuron development.
Development, 2006 Oct , 133 (3827-36).

221

Van Wart A et al. Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels.
J. Neurosci., 2006 Jul 5 , 26 (7172-80).

223

de Ruiter MM et al. Voltage-gated sodium channels in cerebellar Purkinje cells of mormyrid fish.
J. Neurophysiol., 2006 Jul , 96 (378-90).

227

Meisler MH et al. Gene symbol: SCN8A. Disease: Ataxia. Accession #Hd0520.
Hum. Genet., 2006 Feb , 118 (776).

228

Van Wart A et al. Expression of sodium channels Nav1.2 and Nav1.6 during postnatal development of the retina.
Neurosci. Lett., 2006 Aug 7 , 403 (315-7).

231

Leão RN et al. Altered sodium currents in auditory neurons of congenitally deaf mice.
Eur. J. Neurosci., 2006 Aug , 24 (1137-46).

234

Ebensperger G et al. Fetal brain hypometabolism during prolonged hypoxaemia in the llama.
J. Physiol. (Lond.), 2005 Sep 15 , 567 (963-75).

236

Ptak K et al. Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region.
J. Neurosci., 2005 May 25 , 25 (5159-70).

240

Gao Y et al. Linkage mapping of the SCN8A gene to chicken linkage group E22C19W28.
Anim. Genet., 2005 Jun , 36 (284).

242

Wittmack EK et al. Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.
J. Neurosci., 2005 Jul 13 , 25 (6621-30).

245

Devaux JJ et al. Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA.
J. Neurosci., 2005 Feb 9 , 25 (1470-80).

246

Wasserman D et al. Suicide attempt and basic mechanisms in neural conduction: relationships to the SCN8A and VAMP4 genes.
Am. J. Med. Genet. B Neuropsychiatr. Genet., 2005 Feb 5 , 133B (116-9).

249

Meisler MH et al. Sodium channel mutations in epilepsy and other neurological disorders.
J. Clin. Invest., 2005 Aug , 115 (2010-7).

250

Cummins TR et al. Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons.
FEBS Lett., 2005 Apr 11 , 579 (2166-70).

252

Lei M et al. Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking.
J. Physiol. (Lond.), 2004 Sep 15 , 559 (835-48).

264

Zhou W et al. Use-dependent potentiation of the Nav1.6 sodium channel.
Biophys. J., 2004 Dec , 87 (3862-72).

268

Do MT et al. Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice.
J. Neurophysiol., 2004 Aug , 92 (726-33).

279

Rasband MN et al. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination.
J. Neurosci. Res., 2003 Aug 15 , 73 (465-70).

280

Buchner DA et al. SCNM1, a putative RNA splicing factor that modifies disease severity in mice.
Science, 2003 Aug 15 , 301 (967-9).

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284

Alessandri-Haber N et al. Molecular determinants of emerging excitability in rat embryonic motoneurons.
J. Physiol. (Lond.), 2002 May 15 , 541 (25-39).

285

Meisler MH et al. Mutations of voltage-gated sodium channels in movement disorders and epilepsy.
Novartis Found. Symp., 2002 , 241 (72-81; discussion 82-6, 226-32).

288

De Repentigny Y et al. Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a.
Hum. Mol. Genet., 2001 Aug 15 , 10 (1819-27).

289

293

Smith MR et al. A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel.
Neuroreport, 1999 Sep 29 , 10 (3027-31).

294

Chen K et al. Reduced spontaneous activity in the dorsal cochlear nucleus of Scn8a mutant mice.
Brain Res., 1999 Nov 13 , 847 (85-9).

297

Pan F et al. The absence of resurgent sodium current in mouse spinal neurons.
Brain Res., 1999 Dec 4 , 849 (162-8).

301

Smith MR et al. Functional analysis of the mouse Scn8a sodium channel.
J. Neurosci., 1998 Aug 15 , 18 (6093-102).

304

Vega-Saenz de Miera EC et al. Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells.
Proc. Natl. Acad. Sci. U.S.A., 1997 Jun 24 , 94 (7059-64).

305

Meisler MH et al. Ion channel mutations in mouse models of inherited neurological disease.
Ann. Med., 1997 Dec , 29 (569-74).