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PubMed 17088206


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Title: Kv1.1 takes a deTOR from the axon to the dendrite.

Authors: Eliana Clark, Helene Vacher, James S Trimmer

Journal, date & volume: Neuron, 2006 Nov 9 , 52, 399-401

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17088206


Abstract

In the October 6th issue of Science, Raab-Graham et al. described two surprising findings. They discovered that local dendritic translation of Kv1.1 occurs in CA1 dendrites of rat hippocampal slices and in cultured neurons. This local translation is inhibited by NMDA receptor-mediated synaptic signaling acting through the mTOR kinase.