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Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C.

M A Ciorba, S H Heinemann, H Weissbach, N Brot, T Hoshi

FEBS Lett., 1999 Jan 8 , 442, 48-52

Methionine oxidation is known to alter functional properties of a transient A-type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K+ channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C.