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Modulation of Kv2.1 channels inactivation by curcumin.

Iván A Aréchiga-Figueroa, Mayra Delgado-Ramírez, Rita Morán-Zendejas, Aldo A Rodríguez-Menchaca

Pharmacol Rep, 2015 Dec , 67, 1273-9

The aim of the present study was to assess the effects of curcumin on the voltage-dependent Kv2.1 potassium channel.The whole-cell patch-clamp technique was used to explore the regulation of Kv2.1 channels expressed in HEK293 cells by curcumin.Curcumin reduced the Kv2.1 currents; the inhibition occurred with a slow time course and was partially reversible. Curcumin did not alter the kinetics and voltage dependence of activation; however, the kinetics of open- and closed-state inactivation was accelerated by curcumin along with a hyperpolarizing shift in the voltage dependence of inactivation. Curcumin inhibition of Kv2.1 current was not use-dependent.Overall, our data suggest that curcumin inhibits Kv2.1 channels by modulating the inactivation gating, which would be expected to impact cellular physiology.

http://www.ncbi.nlm.nih.gov/pubmed/26481552