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Fast Inactivation of Voltage-Gated K(+) Channels: From Cartoon to Structure.
Antz, Fakler, Christoph Antz, Bernd Fakler
News Physiol. Sci.,
, 13, 177-182
Fast inactivation of voltage-gated potassium (K(v)) channels is the best understood gating transition in ion channels and is brought about by an NH(2)-terminal domain (ball domain) of the channel's alpha-subunit, which physically blocks the open pore. Recent analysis by nuclear magnetic resonance spectroscopy showed that ball domains from various K(v) channels exhibit well-defined but distinct structures in aqueous solution.