Referenced in: none

Automatically associated channels: Kir2.1

Title: Primary structure and functional expression of a mouse inward rectifier potassium channel.

Authors: Y Kubo, T J Baldwin, Y N Jan, L Y Jan

Journal, date & volume: Nature, 1993 Mar 11 , 362, 127-33

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/7680768

Abstract
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.