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All references automaticaly matched for Nav1.7


382. Pubmed Cheng L. et al. Effects of Fluvastatin on Characteristics of Stellate Ganglion Neurons in a Rabbit Model of Myocardial Ischemia. Chin. Med. J., 2016 May , 129 (549-56).
381. Pubmed Gupta B. et al. Antinociceptive properties of shikonin: in vitro and in vivo studies. Can. J. Physiol. Pharmacol., 2016 Mar 6 , (1-9).
380. Pubmed Tao H. et al. Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels. Toxicon, 2016 Mar 1 , 111 (13-21).
379. Pubmed Rogers M. et al. Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening. Assay Drug Dev Technol, 2016 Mar , 14 (109-30).
378. Pubmed Chambers C. et al. High-Throughput Screening of NaV1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument. Assay Drug Dev Technol, 2016 Mar , 14 (93-108).
377. Pubmed Henriques S. et al. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes is a Prerequisite for its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J. Biol. Chem., 2016 Jun 16 , ().
376. Pubmed Xu J. et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia, 2016 Jun , 111 (1-6).
375. Pubmed Cui H. et al. Catalytic asymmetric hetero-Diels-Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives. Org. Biomol. Chem., 2016 Jan 27 , 14 (1777-83).
374. Pubmed Stueber T. et al. Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity. Anesthesiology, 2016 Feb 9 , ().
373. Pubmed Murray J. et al. Single Residue Substitutions That Confer NaV Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1. J. Med. Chem., 2016 Feb 18 , ().
372. Pubmed Shcherbatko A. et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain. J. Biol. Chem., 2016 Apr 22 , ().
371. Pubmed Frost J. et al. Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. J. Med. Chem., 2016 Apr 14 , 59 (3373-91).
370. Pubmed Zhao Y. et al. Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells. BMC Cardiovasc Disord, 2016 , 16 (1).
369. Pubmed Zhang H. et al. Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels. Elife, 2016 , 5 ().
368. Pubmed Lazcano-Pérez F. et al. Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons. Toxins (Basel), 2016 , 8 ().
367. Pubmed Ji R. et al. Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms? Pulm Pharmacol Ther, 2015 Sep 6 , ().
366. Pubmed Salas M. et al. Tetrodotoxin suppresses thermal hyperalgesia and mechanical allodynia in a rat full thickness thermal injury pain model. Neurosci. Lett., 2015 Sep 28 , 607 (108-113).
365. Pubmed Remacle A. et al. Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling. J. Biol. Chem., 2015 Sep 18 , 290 (22939-44).
364. Pubmed Namer B. et al. Specific changes in conduction velocity recovery cycles of single nociceptors in a patient with erythromelalgia with the I848T gain-of-function mutation of Nav1.7. Pain, 2015 Sep , 156 (1637-46).
363. Pubmed Estacion M. et al. Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation. J. Neurophysiol., 2015 Sep , 114 (1554-64).
362. Pubmed Klint J. et al. Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1.7. Mol. Pharmacol., 2015 Oct 1 , ().
361. Pubmed Kim D. et al. Bilateral congenital corneal anesthesia in a patient with SCN9A mutation, confirmed primary erythromelalgia, and paroxysmal extreme pain disorder. J AAPOS, 2015 Oct , 19 (478-9).
360. Pubmed Murray J. et al. Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1. Bioorg. Med. Chem. Lett., 2015 Nov 1 , 25 (4866-71).
359. Pubmed Zheng G. et al. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. Exp. Neurol., 2015 Nov , 273 (301-11).
358. Pubmed Emery E. et al. Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. J. Neurosci., 2015 May 20 , 35 (7674-81).
357. Pubmed Stadler T. et al. Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7. J. Biol. Chem., 2015 Mar 6 , 290 (6316-25).
356. Pubmed Murray J. et al. Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel. J. Med. Chem., 2015 Mar 12 , 58 (2299-314).
355. Pubmed Tigerholm J. et al. C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability. Biophys. J., 2015 Mar 10 , 108 (1057-71).
354. Pubmed Rahman W. et al. Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat. Neuroscience, 2015 Jun 4 , 295 (103-16).
353. Pubmed Hoeijmakers J. et al. Painful peripheral neuropathy and sodium channel mutations. Neurosci. Lett., 2015 Jun 2 , 596 (51-9).
352. Pubmed Du Y. et al. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS Chem Neurosci, 2015 Jun 17 , 6 (871-8).
351. Pubmed Bogdanova-Mihaylova P. et al. SCN9A-associated congenital insensitivity to pain and anosmia in an Irish patient. J. Peripher. Nerv. Syst., 2015 Jun , 20 (86-7).
350. Pubmed Han C. et al. The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy. Neuromolecular Med., 2015 Jun , 17 (158-69).
349. Pubmed Cai T. et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels. Peptides, 2015 Jun , 68 (148-56).
348. Pubmed Torregrosa R. et al. Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels. Bioorg. Med. Chem., 2015 Jul 1 , 23 (3655-66).
347. Pubmed Chow C. et al. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula. Toxins (Basel), 2015 Jul , 7 (2494-513).
346. Pubmed Wang Z. et al. Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions. Acta Pharmacol. Sin., 2015 Jul , 36 (791-9).
345. Pubmed Fukuoka T. et al. De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation. Neuroscience, 2015 Jan 22 , 284 (693-706).
344. Pubmed Lynch S. et al. Dibenzazepines and dibenzoxazepines as sodium channel blockers. Bioorg. Med. Chem. Lett., 2015 Jan 1 , 25 (43-7).
343. Pubmed Lynch S. et al. N-Aryl azacycles as novel sodium channel blockers. Bioorg. Med. Chem. Lett., 2015 Jan 1 , 25 (48-52).
342. Pubmed Stoetzer C. et al. Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves. Br J Anaesth, 2015 Jan , 114 (110-20).
341. Pubmed Lim B. et al. Epilepsy phenotype associated with a chromosome 2q24.3 deletion involving SCN1A: Migrating partial seizures of infancy or atypical Dravet syndrome? Epilepsy Res., 2015 Jan , 109 (34-9).
340. Pubmed Zhang F. et al. Natural mutations change the affinity of μ-theraphotoxin-Hhn2a to voltage-gated sodium channels. Toxicon, 2015 Jan , 93 (24-30).
339. Pubmed Feng B. et al. Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings. J. Neurophysiol., 2015 Feb 4 , (jn.00717.2014).
338. Pubmed Vandael D. et al. Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells. J. Physiol. (Lond.), 2015 Feb 15 , 593 (905-27).
337. Pubmed Suter M. et al. p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder. Anesthesiology, 2015 Feb , 122 (414-23).
336. Pubmed Bi R. et al. A new hypothesis of sex-differences in temporomandibular disorders: estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion? Med. Hypotheses, 2015 Feb , 84 (100-3).
335. Pubmed Obergrussberger A. et al. Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module. J Lab Autom, 2015 Dec 23 , ().
334. Pubmed Ahuja S. et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science, 2015 Dec 18 , 350 (aac5464).
333. Pubmed Spencer N. et al. Switching off pain at the source: is this the end for opioid pain relief? Pain Manag, 2015 Dec 17 , ().
332. Pubmed Szabat M. et al. High-content screening identifies a role for Na(+) channels in insulin production. R Soc Open Sci, 2015 Dec , 2 (150306).
331. Pubmed Cardoso F. et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol. Pharmacol., 2015 Aug , 88 (291-303).
330. Pubmed Pucca M. et al. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages. Biochimie, 2015 Aug , 115 (8-16).
329. Pubmed Matson D. et al. Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain. PLoS ONE, 2015 , 10 (e0138140).
328. Pubmed Habib A. et al. Sodium channels and pain. Handb Exp Pharmacol, 2015 , 227 (39-56).
327. Pubmed Imai N. et al. Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder. J Headache Pain, 2015 , 16 (519).
326. Pubmed Bao L. et al. Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol Pain, 2015 , 11 (61).
325. Pubmed Kharatmal S. et al. Voltage-Gated Sodium Channels as Therapeutic Targets for Treatment of Painful Diabetic Neuropathy. Mini Rev Med Chem, 2015 , 15 (1134-47).
324. Pubmed Wang Y. et al. Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine. PLoS ONE, 2015 , 10 (e0128653).
323. Pubmed Doran C. et al. Mouse DRG Cell Line with Properties of Nociceptors. PLoS ONE, 2015 , 10 (e0128670).
322. Pubmed Koenig J. et al. Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. PLoS ONE, 2015 , 10 (e0128830).
321. Pubmed Rice F. et al. Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin. Mol Pain, 2015 , 11 (26).
320. Pubmed King G. et al. No gain, no pain: NaV1.7 as an analgesic target. ACS Chem Neurosci, 2014 Sep 17 , 5 (749-51).
319. Pubmed Sun S. et al. The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7. Bioorg. Med. Chem. Lett., 2014 Sep 15 , 24 (4397-401).
318. Pubmed Huang J. et al. Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. J. Neurosci., 2014 Sep 10 , 34 (12328-40).
317. Pubmed Ding T. et al. Neural tissue engineering scaffold with sustained RAPA release relieves neuropathic pain in rats. Life Sci., 2014 Sep 1 , 112 (22-32).
316. Pubmed Ho G. et al. Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers. Bioorg. Med. Chem. Lett., 2014 Sep 1 , 24 (4110-3).
315. Pubmed Greaves E. et al. Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis. J. Clin. Endocrinol. Metab., 2014 Sep , 99 (E1738-43).
314. Pubmed Horishita T. et al. Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 expressed in xenopus oocytes. Anesthesiology, 2014 Sep , 121 (620-31).
313. Pubmed Huang Y. et al. The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy. Neurochem. Int., 2014 Sep , 75 (112-9).
312. Pubmed Sun S. et al. Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010. Pharm Pat Anal, 2014 Sep , 3 (509-21).
311. Pubmed Meglič A. et al. Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. Pediatr. Nephrol., 2014 Sep , 29 (1643-6).
310. Pubmed Snyder L. et al. An SCN9A variant, known to cause pain, is now found to cause itch. Pain, 2014 Sep , 155 (1677-8).
309. Pubmed Devigili G. et al. Paroxysmal itch caused by gain-of-function Nav1.7 mutation. Pain, 2014 Sep , 155 (1702-7).
308. Pubmed Ramirez J. et al. Null mutation in SCN9A in which noxious stimuli can be detected in the absence of pain. Neurology, 2014 Oct 21 , 83 (1577-80).
307. Pubmed Harrer J. et al. Neuropathic pain in two-generation twins carrying the sodium channel Nav1.7 functional variant R1150W. Pain, 2014 Oct , 155 (2199-203).
306. Pubmed Green B. et al. Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity. Future Med Chem, 2014 Oct , 6 (1677-98).
305. Pubmed Hoeijmakers J. et al. Channelopathies, painful neuropathy, and diabetes: which way does the causal arrow point? Trends Mol Med, 2014 Oct , 20 (544-50).
304. Pubmed Cregg R. et al. Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels. Br. J. Pharmacol., 2014 Oct , 171 (4455-63).
303. Pubmed Tan Z. et al. Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker. FEBS Lett., 2014 Nov 3 , 588 (3964-9).
302. Pubmed Zhang Q. et al. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. J. Physiol. (Lond.), 2014 Nov 1 , 592 (4677-96).
301. Pubmed Waxman S. et al. Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use. Lancet Neurol, 2014 Nov , 13 (1152-60).
300. Pubmed Xu L. et al. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus. Toxicon, 2014 Nov , 90 (318-25).
299. Pubmed Bartholomew F. et al. Channelopathy: a novel mutation in the SCN9A gene causes insensitivity to pain and autonomic dysregulation. Br. J. Dermatol., 2014 Nov , 171 (1268-70).
298. Pubmed Mansouri M. et al. A novel nonsense mutation in SCN9A in a Moroccan child with congenital insensitivity to pain. Pediatr. Neurol., 2014 Nov , 51 (741-4).
297. Pubmed Klint J. et al. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochem. Pharmacol., 2014 May 15 , 89 (276-86).
296. Pubmed Han C. et al. The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability. J. Neurol. Neurosurg. Psychiatr., 2014 May , 85 (499-505).
295. Pubmed Zidar N. et al. Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators. Eur J Med Chem, 2014 Mar 3 , 74 (23-30).
294. Pubmed Thériault O. et al. Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate. Eur. J. Pharmacol., 2014 Mar 15 , 727 (158-66).
293. Pubmed Okura D. et al. The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes. Anesth. Analg., 2014 Mar , 118 (554-62).
292. Pubmed Black J. et al. Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus. Exp. Neurol., 2014 Mar , 253 (174-9).
291. Pubmed Lee J. et al. A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. Cell, 2014 Jun 5 , 157 (1393-404).
290. Pubmed Coleman N. et al. New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1. Mol. Pharmacol., 2014 Jun 23 , ().
289. Pubmed Bennett D. et al. Painful and painless channelopathies. Lancet Neurol, 2014 Jun , 13 (587-99).
288. Pubmed Zhang H. et al. Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathy. Anesthesiology, 2014 Jun , 120 (1463-75).
287. Pubmed Huang J. et al. Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy. Brain, 2014 Jun , 137 (1627-42).
286. Pubmed Foadi N. et al. Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid. Anesth. Analg., 2014 Jun , 118 (1238-45).
285. Pubmed Brouwer B. et al. Painful neuropathies: the emerging role of sodium channelopathies. J. Peripher. Nerv. Syst., 2014 Jun , 19 (53-65).
284. Pubmed Minett M. et al. Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep, 2014 Jan 30 , 6 (301-12).
283. Pubmed Eberhardt M. et al. Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation. J. Biol. Chem., 2014 Jan 24 , 289 (1971-80).
282. Pubmed Meijer I. et al. An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. Muscle Nerve, 2014 Jan , 49 (134-8).
281. Pubmed Shorer Z. et al. A novel mutation in SCN9A in a child with congenital insensitivity to pain. Pediatr. Neurol., 2014 Jan , 50 (73-6).
280. Pubmed Zhang J. et al. Overexpression of myocardin induces partial transdifferentiation of human-induced pluripotent stem cell-derived mesenchymal stem cells into cardiomyocytes. Physiol Rep, 2014 Feb 1 , 2 (e00237).
279. Pubmed Tamura R. et al. Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-α in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons. Anesth. Analg., 2014 Feb , 118 (318-24).
278. Pubmed Muroi Y. et al. Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough. Lung, 2014 Feb , 192 (15-20).
277. Pubmed Mukai M. et al. Evaluation of behavior and expression of NaV1.7 in dorsal root ganglia after sciatic nerve compression and application of nucleus pulposus in rats. Eur Spine J, 2014 Feb , 23 (463-8).
276. Pubmed Park J. et al. Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. J. Med. Chem., 2014 Aug 14 , 57 (6623-31).
275. Pubmed Liu Y. et al. Synthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain. Toxins (Basel), 2014 Aug , 6 (2363-78).
274. Pubmed Yip T. et al. SCN1A variations and response to multiple antiepileptic drugs. Pharmacogenomics J., 2014 Aug , 14 (385-9).
273. Pubmed Themistocleous A. et al. The clinical approach to small fibre neuropathy and painful channelopathy. Pract Neurol, 2014 Apr 28 , ().
272. Pubmed Sadamasu A. et al. Upregulation of NaV1.7 in dorsal root ganglia after intervertebral disc injury in rats. Spine, 2014 Apr 1 , 39 (E421-6).
271. Pubmed Vasylyev D. et al. Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858H. J. Neurophysiol., 2014 Apr , 111 (1429-43).
270. Pubmed Liu Z. et al. Repeated functional convergent effects of NaV1.7 on acid insensitivity in hibernating mammals. Proc. Biol. Sci., 2014 , 281 (20132950).
269. Pubmed Laedermann C. et al. Ubiquitylation of voltage-gated sodium channels. Handb Exp Pharmacol, 2014 , 221 (231-50).
268. Pubmed Lampert A. et al. Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents. Handb Exp Pharmacol, 2014 , 221 (91-110).
267. Pubmed Zimmer T. et al. Voltage-gated sodium channels in the mammalian heart. Glob Cardiol Sci Pract, 2014 , 2014 (449-63).
266. Pubmed Cao J. et al. Intrathecal injection of fluorocitric acid inhibits the activation of glial cells causing reduced mirror pain in rats. BMC Anesthesiol, 2014 , 14 (119).
265. Pubmed Cioli C. et al. Differences in human cortical gene expression match the temporal properties of large-scale functional networks. PLoS ONE, 2014 , 9 (e115913).
264. Pubmed Gingras J. et al. Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain. PLoS ONE, 2014 , 9 (e105895).
263. Pubmed Petersson M. et al. Differential axonal conduction patterns of mechano-sensitive and mechano-insensitive nociceptors--a combined experimental and modelling study. PLoS ONE, 2014 , 9 (e103556).
262. Pubmed Minett M. et al. Significant determinants of mouse pain behaviour. PLoS ONE, 2014 , 9 (e104458).
261. Pubmed Li Y. et al. Assembly and validation of versatile transcription activator-like effector libraries. Sci Rep, 2014 , 4 (4857).
260. Pubmed Abdelsayed M. et al. Voltage-gated sodium channels: pharmaceutical targets via anticonvulsants to treat epileptic syndromes. Channels (Austin), 2013 May-Jun , 7 (146-52).
259. Pubmed Ahn H. et al. Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons. Brain Res., 2013 Sep 5 , 1529 (165-77).
258. Pubmed Mulley J. et al. Role of the sodium channel SCN9A in genetic epilepsy with febrile seizures plus and Dravet syndrome. Epilepsia, 2013 Sep , 54 (e122-6).
257. Pubmed Wu Z. et al. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain, 2013 Sep , 154 (1778-82).
256. Pubmed Rowe A. et al. Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin. Science, 2013 Oct 25 , 342 (441-6).
255. Pubmed Yang S. et al. Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proc. Natl. Acad. Sci. U.S.A., 2013 Oct 22 , 110 (17534-9).
254. Pubmed Zhang X. et al. Gain-of-function mutations in SCN11A cause familial episodic pain. Am. J. Hum. Genet., 2013 Nov 7 , 93 (957-66).
253. Pubmed Yang Y. et al. Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gate. J. Biol. Chem., 2013 May 10 , 288 (13741-7).
252. Pubmed Kalezic I. et al. In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach. Pharm. Res., 2013 May , 30 (1409-22).
251. Pubmed Estacion M. et al. A new Nav1.7 mutation in an erythromelalgia patient. Biochem. Biophys. Res. Commun., 2013 Mar 1 , 432 (99-104).
250. Pubmed Minassian N. et al. Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (μ-TRTX-Hh2a). J. Biol. Chem., 2013 Jun 12 , ().
249. Pubmed Liang L. et al. Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. J Pain, 2013 Jun , 14 (638-47).
248. Pubmed Revell J. et al. Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena. Peptides, 2013 Jun , 44 (40-6).
247. Pubmed Cregg R. et al. Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia. Neuromolecular Med., 2013 Jun , 15 (265-78).
246. Pubmed McCormack K. et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 16 , 110 (E2724-32).
245. Pubmed Liu Z. et al. Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana. J. Biol. Chem., 2013 Jul 12 , 288 (20392-403).
244. Pubmed Tsunozaki M. et al. A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. J. Physiol. (Lond.), 2013 Jul 1 , 591 (3325-40).
243. Pubmed Galloway C. et al. Increases in inflammatory mediators in DRG implicate in the pathogenesis of painful neuropathy in Type 2 diabetes. Cytokine, 2013 Jul , 63 (1-5).
242. Pubmed Waxman S. et al. Painful Na-channelopathies: an expanding universe. Trends Mol Med, 2013 Jul , 19 (406-9).
241. Pubmed Norinder U. et al. QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform. Bioorg. Med. Chem. Lett., 2013 Jan 1 , 23 (261-3).
240. Pubmed Persson A. et al. Neuropathy-associated Nav1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons. Ann. Neurol., 2013 Jan , 73 (140-5).
239. Pubmed Suter M. et al. Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology, 2013 Jan , 118 (160-72).
238. Pubmed Reeder J. et al. Polymorphism in the SCN9A voltage-gated sodium channel gene associated with interstitial cystitis/bladder pain syndrome. Urology, 2013 Jan , 81 (210.e1-4).
237. Pubmed Zhang J. et al. Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons. Brain Res., 2013 Feb 1 , 1493 (13-8).
236. Pubmed Duan G. et al. A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population. Anesthesiology, 2013 Feb , 118 (436-42).
235. Pubmed Zhang L. et al. [Association between mutations of SCN9A gene and pain related to Parkinsonism]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2013 Feb , 30 (17-20).
234. Pubmed Tanzi S. et al. Ion channel recordings on an injection-molded polymer chip. Lab Chip, 2013 Dec 21 , 13 (4784-93).
233. Pubmed Staunton C. et al. Ion channels and osteoarthritic pain: potential for novel analgesics. Curr Pain Headache Rep, 2013 Dec , 17 (378).
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219. Pubmed Zhou X. et al. Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats. PLoS ONE, 2013 , 8 (e74390).
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207. Pubmed Hodgdon K. et al. Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels. Neuroscience, 2012 Mar 29 , 206 (237-44).
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201. Pubmed Nguyen H. et al. Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorg. Med. Chem. Lett., 2012 Jan 15 , 22 (1055-60).
200. Pubmed Fu L. et al. Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: A possible basis for modulation of excitability in vivo. , 2012 Jan 1 , 6 ().
199. Pubmed Faber C. et al. Gain of function Naν1.7 mutations in idiopathic small fiber neuropathy. Ann. Neurol., 2012 Jan , 71 (26-39).
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192. Pubmed Ding H. et al. Alterations of gene expression of sodium channels in dorsal root ganglion neurons of estrogen receptor knockout (ERKO) mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Endocrine, 2012 Aug , 42 (118-24).
191. Pubmed Hu F. et al. 17β-Estradiol regulates the gene expression of voltage-gated sodium channels: role of estrogen receptor α and estrogen receptor β. Endocrine, 2012 Apr , 41 (274-80).
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189. Pubmed Weinkauf B. et al. Local Gene Expression Changes after UV-Irradiation of Human Skin. PLoS ONE, 2012 , 7 (e39411).
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187. Pubmed Vargas-Alarcón G. et al. A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia. BMC Musculoskelet Disord, 2012 , 13 (23).
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183. Pubmed Farmer C. et al. Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical properties. PLoS ONE, 2012 , 7 (e41750).
182. Pubmed Rong M. et al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J., 2011 Sep , 25 (3177-85).
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179. Pubmed Byers M. et al. Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels. Arch. Oral Biol., 2011 Nov , 56 (1199-220).
178. Pubmed Freilich E. et al. Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy. Arch. Neurol., 2011 May , 68 (665-71).
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172. Pubmed Fukuoka T. et al. Comparative study of voltage-gated sodium channel α-subunits in non-overlapping four neuronal populations in the rat dorsal root ganglion. Neurosci. Res., 2011 Jun , 70 (164-71).
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163. Pubmed Theile J. et al. Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents. J. Physiol. (Lond.), 2011 Feb 1 , 589 (597-608).
162. Pubmed Panigel J. et al. A point mutation at F1737 of the human Nav1.7 sodium channel decreases inhibition by local anesthetics. J. Neurogenet., 2011 Dec , 25 (134-9).
161. Pubmed Xiao Y. et al. Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV. J. Biol. Chem., 2011 Aug 5 , 286 (27301-10).
160. Pubmed Kis-Toth K. et al. Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset. J. Immunol., 2011 Aug 1 , 187 (1273-80).
159. Pubmed Persson A. et al. NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas. Exp. Neurol., 2011 Aug , 230 (273-9).
158. Pubmed Weiss J. et al. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature, 2011 Apr 14 , 472 (186-90).
157. Pubmed Gurkiewicz M. et al. Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. J. Neurophysiol., 2011 Apr , 105 (1546-57).
156. Pubmed Ahn H. et al. Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons. Mol Pain, 2011 , 7 (32).
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154. Pubmed Zhang L. et al. Long-term remission of primary erythermalgia with R1150W polymorphism in SCN9A after chemical lumbar sympathectomy. Eur J Dermatol, 2010 Nov-Dec , 20 (763-7).
153. Pubmed Tyagarajan S. et al. Substituted biaryl pyrazoles as sodium channel blockers. Bioorg. Med. Chem. Lett., 2010 Sep 15 , 20 (5480-3).
152. Pubmed Fukuoka T. et al. Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord. Neuroscience, 2010 Sep 1 , 169 (994-1006).
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135. Pubmed Estacion M. et al. Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation. , 2010 Feb 1 , ().
134. Pubmed Chioni A. et al. Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int. J. Biochem. Cell Biol., 2010 Feb , 42 (346-58).
133. Pubmed Xiao Y. et al. The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation. Mol. Pharmacol., 2010 Dec , 78 (1124-34).
132. Pubmed Guerrini R. et al. Variable epilepsy phenotypes associated with a familial intragenic deletion of the SCN1A gene. Epilepsia, 2010 Dec , 51 (2474-7).
131. Pubmed Nemoto T. et al. Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38. Eur. J. Pharmacol., 2010 Aug 25 , 640 (20-8).
130. Pubmed Ghelardini C. et al. Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models. Neuroscience, 2010 Aug 25 , 169 (863-73).
129. Pubmed Estacion M. et al. A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons. Exp. Neurol., 2010 Aug , 224 (362-8).
128. Pubmed Krupp J. et al. Linkage analysis and functional evaluation of inherited clinical pain conditions. Methods Mol. Biol., 2010 , 617 (309-25).
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120. Pubmed Zsiros E. et al. Developmental switch of the expression of ion channels in human dendritic cells. J. Immunol., 2009 Oct 1 , 183 (4483-92).
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116. Pubmed Wang G. et al. State-dependent block of Na+ channels by articaine via the local anesthetic receptor. J. Membr. Biol., 2009 May , 229 (1-9).
115. Pubmed Fischer T. et al. A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia. Ann. Neurol., 2009 Jun , 65 (733-41).
114. Pubmed Kanai T. et al. Nav1.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3beta in adrenal chromaffin cells. Neurochem. Int., 2009 Jul , 54 (497-505).
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110. Pubmed Nakajima T. et al. Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells. Br. J. Pharmacol., 2009 Feb , 156 (420-31).
109. Pubmed Onkal R. et al. Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer. Eur. J. Pharmacol., 2009 Dec 25 , 625 (206-19).
108. Pubmed Lampert A. et al. Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials. Biochem. Biophys. Res. Commun., 2009 Dec 11 , 390 (319-24).
107. Pubmed Siqueira S. et al. Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia. Neuroscience, 2009 Dec 1 , 164 (573-7).
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105. Pubmed Natkunarajah J. et al. Treatment with carbamazepine and gabapentin of a patient with primary erythermalgia (erythromelalgia) identified to have a mutation in the SCN9A gene, encoding a voltage-gated sodium channel. Clin. Exp. Dermatol., 2009 Dec , 34 (e640-2).
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96. Pubmed Fukuoka T. et al. Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons. J. Comp. Neurol., 2008 Sep 10 , 510 (188-206).
95. Pubmed Jarecki B. et al. Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. J. Physiol. (Lond.), 2008 Sep 1 , 586 (4137-53).
94. Pubmed Xiao Y. et al. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration. J. Biol. Chem., 2008 Oct 3 , 283 (27300-13).
93. Pubmed Estacion M. et al. NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders. J. Neurosci., 2008 Oct 22 , 28 (11079-88).
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91. Pubmed Nyholt D. et al. A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum. Mol. Genet., 2008 Nov 1 , 17 (3318-31).
90. Pubmed Schmalhofer W. et al. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol. Pharmacol., 2008 Nov , 74 (1476-84).
89. Pubmed London C. et al. Imidazopyridines: a novel class of hNav1.7 channel blockers. Bioorg. Med. Chem. Lett., 2008 Mar 1 , 18 (1696-701).
88. Pubmed Wang G. et al. State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol. Pharmacol., 2008 Mar , 73 (940-8).
87. Pubmed Diss J. et al. Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (SCN9A). Mol. Cell. Neurosci., 2008 Mar , 37 (537-47).
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85. Pubmed Drenth J. et al. Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A. Arch Dermatol, 2008 Mar , 144 (320-4).
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83. Pubmed Chattopadhyay M. et al. Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. J. Neurosci., 2008 Jun 25 , 28 (6652-8).
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78. Pubmed Kort M. et al. Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. J. Med. Chem., 2008 Feb 14 , 51 (407-16).
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