User Visitor Login
English only
EPFL > FSV > BBP > Channelpedia
Ion channels
Logged in as a Visitor.

All references automaticaly matched for Nav1.2

202. Pubmed Tao H. et al. Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels. Toxicon, 2016 Mar 1 , 111 (13-21).
201. Pubmed Rogers M. et al. Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening. Assay Drug Dev Technol, 2016 Mar , 14 (109-30).
200. Pubmed Arias H. et al. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. Int. J. Biochem. Cell Biol., 2016 Jul , 76 (19-30).
199. Pubmed Green B. et al. Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem., 2016 Jan 27 , ().
198. Pubmed Benned-Jensen T. et al. Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed. J. Neurosci., 2016 Feb 17 , 36 (2261-6).
197. Pubmed Murenzi E. et al. Evaluation of microtransplantation of rat brain neurolemma into Xenopus laevis oocytes as a technique to study the effect of neurotoxicants on endogenous voltage-sensitive ion channels. Neurotoxicology, 2016 Apr 7 , ().
196. Pubmed Branch S. et al. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. J. Neurosci., 2016 Apr 6 , 36 (4026-37).
195. Pubmed Shcherbatko A. et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain. J. Biol. Chem., 2016 Apr 22 , ().
194. Pubmed Wildburger N. et al. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. Mol. Cell Proteomics, 2015 May , 14 (1288-300).
193. Pubmed Mishra S. et al. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts. J. Physiol. (Lond.), 2015 Mar 15 , 593 (1409-27).
192. Pubmed Gazina E. et al. 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. Hum. Mol. Genet., 2015 Mar 1 , 24 (1457-68).
191. Pubmed Zhang M. et al. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry, 2015 Jun 30 , 54 (3911-20).
190. Pubmed Fukasawa T. et al. A case of recurrent encephalopathy with SCN2A missense mutation. Brain Dev., 2015 Jun , 37 (631-4).
189. Pubmed Cai T. et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels. Peptides, 2015 Jun , 68 (148-56).
188. Pubmed Xu M. et al. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. J. Biol. Chem., 2015 Jul 3 , 290 (16619-32).
187. Pubmed Chow C. et al. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula. Toxins (Basel), 2015 Jul , 7 (2494-513).
186. Pubmed Slowik D. et al. Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference. Biochim. Biophys. Acta, 2015 Jul , 1848 (1545-51).
185. Pubmed Pucca M. et al. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom. Toxins (Basel), 2015 Jul , 7 (2534-50).
184. Pubmed Wang M. et al. [Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats]. Zhonghua Yi Xue Za Zhi, 2015 Jan 6 , 95 (61-5).
183. Pubmed Stoetzer C. et al. Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves. Br J Anaesth, 2015 Jan , 114 (110-20).
182. Pubmed Kancherla A. et al. A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin. ACS Chem. Biol., 2015 Aug 21 , 10 (1847-60).
181. Pubmed Cardoso F. et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol. Pharmacol., 2015 Aug , 88 (291-303).
180. Pubmed Pucca M. et al. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages. Biochimie, 2015 Aug , 115 (8-16).
179. Pubmed Zúñiga-García V. et al. Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. Dig. Dis. Sci., 2015 Apr 5 , ().
178. Pubmed Guo F. et al. Low-Mg(2+) treatment increases sensitivity of voltage-gated Na(+) channels to Ca(2+)/calmodulin-mediated modulation in cultured hippocampal neurons. Am. J. Physiol., Cell Physiol., 2015 Apr 15 , 308 (C594-605).
177. Pubmed James T. et al. The Nav1.2 channel is regulated by GSK3. Biochim. Biophys. Acta, 2015 Apr , 1850 (832-44).
176. Pubmed Zhang C. et al. 17β-Estradiol increases persistent Na(+) current and excitability of AVPV/PeN Kiss1 neurons in female mice. Mol. Endocrinol., 2015 Apr , 29 (518-27).
175. Pubmed Sun L. et al. MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion. Mol Neurodegener, 2015 , 10 (36).
174. Pubmed Chen W. et al. Tumor necrosis factor-α enhances voltage-gated Na⁺ currents in primary culture of mouse cortical neurons. J Neuroinflammation, 2015 , 12 (126).
173. Pubmed Li T. et al. Action potential initiation in neocortical inhibitory interneurons. PLoS Biol., 2014 Sep , 12 (e1001944).
172. Pubmed Horishita T. et al. Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 expressed in xenopus oocytes. Anesthesiology, 2014 Sep , 121 (620-31).
171. Pubmed Gur Barzilai M. et al. The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels. Biochem. J., 2014 Oct 15 , 463 (271-7).
170. Pubmed Green B. et al. Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity. Future Med Chem, 2014 Oct , 6 (1677-98).
169. Pubmed Foadi N. et al. A combination of topical antiseptics for the treatment of sore throat blocks voltage-gated neuronal sodium channels. Naunyn Schmiedebergs Arch. Pharmacol., 2014 Oct , 387 (991-1000).
168. Pubmed Xu L. et al. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus. Toxicon, 2014 Nov , 90 (318-25).
167. Pubmed Baek J. et al. Reciprocal Changes in Phosphorylation and Methylation of Mammalian Brain Sodium Channels in Response to Seizures. J. Biol. Chem., 2014 May 30 , 289 (15363-15373).
166. Pubmed Gilchrist J. et al. Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents. ACS Chem. Biol., 2014 May 16 , 9 (1204-12).
165. Pubmed Gui J. et al. A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr. Biol., 2014 Mar 3 , 24 (473-83).
164. Pubmed Okura D. et al. The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes. Anesth. Analg., 2014 Mar , 118 (554-62).
163. Pubmed Black J. et al. Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus. Exp. Neurol., 2014 Mar , 253 (174-9).
162. Pubmed Coleman N. et al. New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1. Mol. Pharmacol., 2014 Jun 23 , ().
161. Pubmed Li H. et al. GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells. Biochim. Biophys. Acta, 2014 Jun , 1840 (2060-9).
160. Pubmed Foadi N. et al. Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid. Anesth. Analg., 2014 Jun , 118 (1238-45).
159. Pubmed Oliva M. et al. Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy. Neurobiol. Dis., 2014 Jul , 67 (180-90).
158. Pubmed Lee J. et al. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes. Acta Pharmacol. Sin., 2014 Jul , 35 (862-8).
157. Pubmed Barry J. et al. Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons. Dev. Cell, 2014 Jan 27 , 28 (117-31).
156. Pubmed Gajewiak J. et al. A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proc. Natl. Acad. Sci. U.S.A., 2014 Feb 18 , 111 (2758-63).
155. Pubmed Magdaleno-Méndez A. et al. Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes. Endocrine, 2014 Aug 24 , ().
154. Pubmed Park J. et al. Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. J. Med. Chem., 2014 Aug 14 , 57 (6623-31).
153. Pubmed Bouafia A. et al. Axonal expression of sodium channels and neuropathology of the plaques in multiple sclerosis. Neuropathol. Appl. Neurobiol., 2014 Aug , 40 (579-90).
152. Pubmed Makinson C. et al. Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance. Neurobiol. Dis., 2014 Aug , 68 (16-25).
151. Pubmed Wang C. et al. Structural basis of diverse membrane target recognitions by ankyrins. Elife, 2014 , 3 ().
150. Pubmed Zimmer T. et al. Voltage-gated sodium channels in the mammalian heart. Glob Cardiol Sci Pract, 2014 , 2014 (449-63).
149. Pubmed Wang Z. et al. Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. PLoS ONE, 2014 , 9 (e113272).
148. Pubmed Liu Z. et al. PKA phosphorylation reshapes the pharmacological kinetics of BmK AS, a unique site-4 sodium channel-specific modulator. Sci Rep, 2014 , 4 (3721).
147. Pubmed Abdelsayed M. et al. Voltage-gated sodium channels: pharmaceutical targets via anticonvulsants to treat epileptic syndromes. Channels (Austin), 2013 May-Jun , 7 (146-52).
146. Pubmed Pérez-Medina C. et al. Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels. Bioorg. Med. Chem. Lett., 2013 Sep 15 , 23 (5170-3).
145. Pubmed Zhu L. et al. Two recombinant α-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels. Biochimie, 2013 Sep , 95 (1732-40).
144. Pubmed Qiao X. et al. Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy. Epilepsy Res., 2013 Sep , 106 (17-28).
143. Pubmed Yang S. et al. Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proc. Natl. Acad. Sci. U.S.A., 2013 Oct 22 , 110 (17534-9).
142. Pubmed Westenbroek R. et al. Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry. J. Mol. Cell. Cardiol., 2013 Nov , 64 (69-78).
141. Pubmed Kendel Y. et al. Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors. Toxins (Basel), 2013 May , 5 (1043-50).
140. Pubmed Minassian N. et al. Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (μ-TRTX-Hh2a). J. Biol. Chem., 2013 Jun 12 , ().
139. Pubmed Walewska A. et al. Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues. Eur J Med Chem, 2013 Jul , 65 (144-50).
138. Pubmed Xu X. et al. Abnormal changes in voltage-gated sodium channels Na(V)1.1, Na(V)1.2, Na(V)1.3, Na(V)1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats. Brain Res. Bull., 2013 Jul , 96 (1-9).
137. Pubmed Gilchrist J. et al. Crystallographic insights into sodium-channel modulation by the β4 subunit. Proc. Natl. Acad. Sci. U.S.A., 2013 Dec 17 , 110 (E5016-24).
136. Pubmed Bradley E. et al. The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells. Am. J. Physiol., Cell Physiol., 2013 Aug 15 , 305 (C427-35).
135. Pubmed Stevens M. et al. Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis. J. Neuroimmunol., 2013 Aug 15 , 261 (21-8).
134. Pubmed Kamiński K. et al. Synthesis and biological properties of new N-Mannich bases derived from 3-methyl-3-phenyl- and 3,3-dimethyl-succinimides. Part V. Eur J Med Chem, 2013 Aug , 66 (12-21).
133. Pubmed Kaufmann S. et al. Distribution and function of sodium channel subtypes in human atrial myocardium. J. Mol. Cell. Cardiol., 2013 Aug , 61 (133-41).
132. Pubmed Mourão C. et al. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family. Biochemistry, 2013 Apr 9 , 52 (2440-52).
131. Pubmed Black J. et al. NaV1.7: stress-induced changes in immunoreactivity within magnocellular neurosecretory neurons of the supraoptic nucleus. Mol Pain, 2013 , 9 (39).
130. Pubmed Davood A. et al. Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore. Med Chem, 2012 Sep , 8 (953-63).
129. Pubmed Abe H. et al. Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells. Proc. Natl. Acad. Sci. U.S.A., 2012 May 29 , 109 (8734-9).
128. Pubmed Hodgdon K. et al. Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels. Neuroscience, 2012 Mar 29 , 206 (237-44).
127. Pubmed Egri C. et al. A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation. Epilepsia, 2012 Mar , 53 (494-505).
126. Pubmed Power K. et al. Modulation of voltage-gated sodium channels hyperpolarizes the voltage threshold for activation in spinal motoneurones. Exp Brain Res, 2012 Mar , 217 (311-22).
125. Pubmed Favreau P. et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Br. J. Pharmacol., 2012 Jul , 166 (1654-68).
124. Pubmed Park J. et al. Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II. J. Pept. Sci., 2012 Jul , 18 (442-8).
123. Pubmed Fu L. et al. Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: A possible basis for modulation of excitability in vivo. , 2012 Jan 1 , 6 ().
122. Pubmed Huang C. et al. Co-expression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. , 2012 Apr 2 , ().
121. Pubmed Foadi N. et al. Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel. Pharmacology, 2012 , 89 (295-302).
120. Pubmed Gao X. et al. Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels. PLoS ONE, 2012 , 7 (e49384).
119. Pubmed Manno I. et al. Environmental enrichment reduces spontaneous seizures in the Q54 transgenic mouse model of temporal lobe epilepsy. Epilepsia, 2011 Sep , 52 (e113-7).
118. Pubmed Abe H. et al. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Proc. Natl. Acad. Sci. U.S.A., 2011 Jul 26 , 108 (12497-502).
117. Pubmed De Oliveira E. et al. Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers. Bioorg. Med. Chem., 2011 Jul 15 , 19 (4322-9).
116. Pubmed Ho C. et al. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons. Mol. Cell. Neurosci., 2011 Jan , 46 (159-66).
115. Pubmed Chen Z. et al. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. , 2011 Feb 9 , ().
114. Pubmed Bosmans F. et al. Palmitoylation influences the function and pharmacology of sodium channels. Proc. Natl. Acad. Sci. U.S.A., 2011 Dec 13 , 108 (20213-8).
113. Pubmed Baroni D. et al. Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines. J. Bioenerg. Biomembr., 2011 Dec , 43 (729-38).
112. Pubmed Liu Y. et al. Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2. Assay Drug Dev Technol, 2011 Dec , 9 (628-34).
111. Pubmed Hildebrand M. et al. Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons. Mol Pain, 2011 , 7 (67).
110. Pubmed He H. et al. Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability. Biochem. J., 2010 Sep 28 , 431 (289-98).
109. Pubmed Fukuoka T. et al. Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord. Neuroscience, 2010 Sep 1 , 169 (994-1006).
108. Pubmed Brachet A. et al. Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier. J. Cell Biol., 2010 Oct 18 , 191 (383-95).
107. Pubmed Gao R. et al. Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer. Oncol. Rep., 2010 May , 23 (1293-9).
106. Pubmed Black J. et al. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5. Brain, 2010 Mar , 133 (835-46).
105. Pubmed Berendt F. et al. Multi-site Phosphorylation of Voltage-Gated Sodium Channel alpha Subunits from Rat Brain. , 2010 Feb 5 , ().
104. Pubmed Osorio N. et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. J. Physiol. (Lond.), 2010 Feb 15 , 588 (651-70).
103. Pubmed Cheng H. et al. Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine. Neurosci Bull, 2010 Aug , 26 (289-96).
102. Pubmed Lenkey N. et al. Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study. PLoS ONE, 2010 , 5 (e15568).
101. Pubmed Cao Z. et al. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits. BMC Neurosci, 2010 , 11 (154).
100. Pubmed Zhang M. et al. Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin), 2009 Jan-Feb , 3 (32-8).
99. Pubmed Abbas N. et al. Full characterization of three toxins from the Androctonus amoreuxi scorpion venom. Toxicon, 2009 Sep 15 , 54 (460-70).
98. Pubmed Laezza F. et al. FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels. Mol. Cell. Neurosci., 2009 Oct , 42 (90-101).
97. Pubmed Fantini M. et al. 2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships. Bioorg. Med. Chem., 2009 May 15 , 17 (3642-8).
96. Pubmed Miloushev V. et al. Solution structure of the NaV1.2 C-terminal EF-hand domain. J. Biol. Chem., 2009 Mar 6 , 284 (6446-54).
95. Pubmed Zhu M. et al. The alpha-like scorpion toxin BmK I enhances membrane excitability via persistent sodium current by preventing slow inactivation and deactivation of rNav1.2a expressed in Xenopus Oocytes. Toxicol In Vitro, 2009 Jun , 23 (561-8).
94. Pubmed Tan J. et al. Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. Neurotoxicology, 2009 Jan , 30 (81-9).
93. Pubmed Huth T. et al. Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function. Neurobiol. Dis., 2009 Feb , 33 (282-9).
92. Pubmed Osorio N. et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. , 2009 Dec 21 , ().
91. Pubmed Zhu M. et al. U-shaped dose-dependent effects of BmK AS, a unique scorpion polypeptide toxin, on voltage-gated sodium channels. Br. J. Pharmacol., 2009 Dec , 158 (1895-903).
90. Pubmed Black J. et al. Sodium channel activity modulates multiple functions in microglia. Glia, 2009 Aug 1 , 57 (1072-81).
89. Pubmed Misra S. et al. Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia, 2008 Sep , 49 (1535-45).
88. Pubmed Xiao Y. et al. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration. J. Biol. Chem., 2008 Oct 3 , 283 (27300-13).
87. Pubmed Huth T. et al. Four-mode gating model of fast inactivation of sodium channel Nav1.2a. Pflugers Arch., 2008 Oct , 457 (103-19).
86. Pubmed Duflocq A. et al. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Mol. Cell. Neurosci., 2008 Oct , 39 (180-92).
85. Pubmed Lee J. et al. Modifications of aliphatic side chain of 20(S)-ginsenoside RG3 cause an enhancement or loss of brain Na+ channel current inhibitions. Biol. Pharm. Bull., 2008 Mar , 31 (480-6).
84. Pubmed Theoharis N. et al. The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin. Biochemistry, 2008 Jan 8 , 47 (112-23).
83. Pubmed Kort M. et al. Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. J. Med. Chem., 2008 Feb 14 , 51 (407-16).
82. Pubmed Black J. et al. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann. Neurol., 2008 Dec , 64 (644-53).
81. Pubmed Lee J. et al. Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated Na+ channel regulation. Brain Res., 2008 Apr 8 , 1203 (61-7).
80. Pubmed Tan M. et al. Effects of BmK AS on Nav1.2 expressed in Xenopus laevis oocytes. Cell Biol. Toxicol., 2008 Apr , 24 (143-9).
79. Pubmed Kaneko Y. et al. Expression of Nav1.1 in rat retinal AII amacrine cells. Neurosci. Lett., 2007 Sep 7 , 424 (83-8).
78. Pubmed Black J. et al. Sodium channel expression within chronic multiple sclerosis plaques. J. Neuropathol. Exp. Neurol., 2007 Sep , 66 (828-37).
77. Pubmed Seda M. et al. Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant rats. Biol. Reprod., 2007 Nov , 77 (855-63).
76. Pubmed Fry M. et al. Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture. J. Neurochem., 2007 May , 101 (737-48).
75. Pubmed Lee J. et al. Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. Eur. J. Pharmacol., 2007 Jun 14 , 564 (7-17).
74. Pubmed Du Y. et al. Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat. Pflugers Arch., 2007 Jun , 454 (451-9).
73. Pubmed Xu R. et al. A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel. Mol. Cell. Neurosci., 2007 Jun , 35 (292-301).
72. Pubmed Ouyang W. et al. Isoform-selective effects of isoflurane on voltage-gated Na+ channels. Anesthesiology, 2007 Jul , 107 (91-8).
71. Pubmed Bosmans F. et al. Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity. Toxicol. Appl. Pharmacol., 2007 Jan 1 , 218 (45-51).
70. Pubmed Huang X. et al. [Expression and function of voltage-gated Na+ channel isoforms in rat sinoatrial node] Nan Fang Yi Ke Da Xue Xue Bao, 2007 Jan , 27 (52-5).
69. Pubmed Corzo G. et al. Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels. J. Biol. Chem., 2007 Feb 16 , 282 (4643-52).
68. Pubmed Watkins J. et al. Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes. Toxicol In Vitro, 2007 Dec , 21 (1672-7).
67. Pubmed Xu R. et al. Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience, 2007 Aug 10 , 148 (164-74).
66. Pubmed Johnson D. et al. Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating. J. Biol. Chem., 2006 Sep 8 , 281 (25875-81).
65. Pubmed Chai Z. et al. Chinese-scorpion (Buthus martensi Karsch) toxin BmK alphaIV, a novel modulator of sodium channels: from genomic organization to functional analysis. Biochem. J., 2006 Nov 1 , 399 (445-53).
64. Pubmed Diniz M. et al. Functional expression and purification of recombinant Tx1, a sodium channel blocker neurotoxin from the venom of the Brazilian "armed" spider, Phoneutria nigriventer. Protein Expr. Purif., 2006 Nov , 50 (18-24).
63. Pubmed Weiser T. et al. Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels. Neurosci. Lett., 2006 Mar 13 , 395 (179-84).
62. Pubmed Li G. et al. Ion channels in mesenchymal stem cells from rat bone marrow. Stem Cells, 2006 Jun , 24 (1519-28).
61. Pubmed de Ruiter M. et al. Voltage-gated sodium channels in cerebellar Purkinje cells of mormyrid fish. J. Neurophysiol., 2006 Jul , 96 (378-90).
60. Pubmed Leipold E. et al. Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3. Mol. Pharmacol., 2006 Jul , 70 (340-7).
59. Pubmed Musarella M. et al. Expression of Nav1.6 sodium channels by Schwann cells at neuromuscular junctions: role in the motor endplate disease phenotype. Glia, 2006 Jan 1 , 53 (13-23).
58. Pubmed Benjamin E. et al. State-dependent compound inhibition of Nav1.2 sodium channels using the FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agents. , 2006 Feb , 11 (29-39).
57. Pubmed Hudgens D. et al. Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2. Bioorg. Med. Chem., 2006 Dec 15 , 14 (8366-78).
56. Pubmed Van Wart A. et al. Expression of sodium channels Nav1.2 and Nav1.6 during postnatal development of the retina. Neurosci. Lett., 2006 Aug 7 , 403 (315-7).
55. Pubmed Jarnot M. et al. Immunolocalization of NaV1.2 channel subtypes in rat and cat brain and spinal cord with high affinity antibodies. Brain Res., 2006 Aug 30 , 1107 (1-12).
54. Pubmed Majumdar S. et al. G-protein activation modulates pseudo-periodic oscillation of Na channel. Biochem. Biophys. Res. Commun., 2006 Aug 25 , 347 (444-51).
53. Pubmed Liu Y. et al. Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin. Epilepsy Res., 2006 Aug , 70 (263-8).
52. Pubmed Zhao P. et al. Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury. , 2006 , 2 (27).
51. Pubmed Ebensperger G. et al. Fetal brain hypometabolism during prolonged hypoxaemia in the llama. J. Physiol. (Lond.), 2005 Sep 15 , 567 (963-75).
50. Pubmed Ye X. et al. Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1. J. Mol. Biol., 2005 Nov 4 , 353 (788-803).
49. Pubmed Ptak K. et al. Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region. J. Neurosci., 2005 May 25 , 25 (5159-70).
48. Pubmed Rush A. et al. Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. J. Physiol. (Lond.), 2005 May 1 , 564 (803-15).
47. Pubmed Srairi-Abid N. et al. A new type of scorpion Na+-channel-toxin-like polypeptide active on K+ channels. Biochem. J., 2005 Jun 1 , 388 (455-64).
46. Pubmed Hossain W. et al. Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea. J. Neurosci., 2005 Jul 20 , 25 (6857-68).
45. Pubmed Thimmapaya R. et al. Distribution and functional characterization of human Nav1.3 splice variants. Eur. J. Neurosci., 2005 Jul , 22 (1-9).
44. Pubmed Rush A. et al. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur. J. Neurosci., 2005 Jul , 22 (39-49).
43. Pubmed Kim J. et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition. Mol. Cells, 2005 Feb 28 , 19 (137-42).
42. Pubmed Osorio N. et al. Differential targeting and functional specialization of sodium channels in cultured cerebellar granule cells. J. Physiol. (Lond.), 2005 Dec 15 , 569 (801-16).
41. Pubmed Liu L. et al. Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1. FASEB J., 2005 Apr , 19 (594-6).
40. Pubmed Mechaly I. et al. Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells. Neuroscience, 2005 , 130 (389-96).
39. Pubmed Kim J. et al. Calmodulin mediates Ca2+ sensitivity of sodium channels. J. Biol. Chem., 2004 Oct 22 , 279 (45004-12).
38. Pubmed Craner M. et al. Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc. Natl. Acad. Sci. U.S.A., 2004 May 25 , 101 (8168-73).
37. Pubmed Suzuki A. et al. Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice. Glia, 2004 May , 46 (274-83).
36. Pubmed Klein J. et al. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res., 2004 Mar 12 , 1000 (102-9).
35. Pubmed Padmashri R. et al. Functional characterization of the pentapeptide QYNAD on rNav1.2 channels and its NMR structure. Pflugers Arch., 2004 Mar , 447 (895-907).
34. Pubmed Leipold E. et al. Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3. Mol. Pharmacol., 2004 Mar , 65 (685-91).
33. Pubmed Vennekamp J. et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol. Pharmacol., 2004 Jun , 65 (1364-74).
32. Pubmed Majumdar S. et al. Induction of pseudo-periodic oscillation in voltage-gated sodium channel properties is dependent on the duration of prolonged depolarization. Eur. J. Neurosci., 2004 Jul , 20 (127-43).
31. Pubmed Grieco T. et al. Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin. J. Neurosci., 2004 Jan 7 , 24 (35-42).
30. Pubmed Belyaev N. et al. Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes. J. Biol. Chem., 2004 Jan 2 , 279 (556-61).
29. Pubmed Barbier J. et al. A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles. J. Biol. Chem., 2004 Feb 6 , 279 (4680-5).
28. Pubmed Zhou W. et al. Use-dependent potentiation of the Nav1.6 sodium channel. Biophys. J., 2004 Dec , 87 (3862-72).
27. Pubmed McNulty M. et al. State-dependent mibefradil block of Na+ channels. Mol. Pharmacol., 2004 Dec , 66 (1652-61).
26. Pubmed Weiser T. et al. A novel toxicity-based assay for the identification of modulators of voltage-gated Na+ channels. J. Neurosci. Methods, 2004 Aug 15 , 137 (79-85).
25. Pubmed McEwen D. et al. Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. J. Biol. Chem., 2004 Apr 16 , 279 (16044-9).
24. Pubmed Sudarslal S. et al. Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail. FEBS Lett., 2003 Oct 9 , 553 (209-12).
23. Pubmed Garrido J. et al. Dynamic compartmentalization of the voltage-gated sodium channels in axons. Biol. Cell, 2003 Oct , 95 (437-45).
22. Pubmed Chabbert C. et al. Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development. J. Physiol. (Lond.), 2003 Nov 15 , 553 (113-23).
21. Pubmed Rasband M. et al. Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons. Glia, 2003 Nov , 44 (173-82).
20. Pubmed Anderson J. et al. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Mol. Cancer Ther., 2003 Nov , 2 (1149-54).
19. Pubmed Moran O. et al. Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in Mammalian cells. Biophys. J., 2003 May , 84 (2999-3006).
18. Pubmed Garrido J. et al. A targeting motif involved in sodium channel clustering at the axonal initial segment. Science, 2003 Jun 27 , 300 (2091-4).
17. Pubmed Craner M. et al. Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Brain, 2003 Jul , 126 (1552-61).
16. Pubmed Qin N. et al. Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur. J. Biochem., 2003 Dec , 270 (4762-70).
15. Pubmed Rios J. et al. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J. Neurosci., 2003 Aug 6 , 23 (7001-11).
14. Pubmed Yu F. et al. Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J. Neurosci., 2003 Aug 20 , 23 (7577-85).
13. Pubmed Vega A. et al. L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells. Brain Res. Mol. Brain Res., 2003 Aug 19 , 116 (115-25).
12. Pubmed Rasband M. et al. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination. J. Neurosci. Res., 2003 Aug 15 , 73 (465-70).
11. Pubmed Schaller K. et al. Expression and distribution of voltage-gated sodium channels in the cerebellum. Cerebellum, 2003 , 2 (2-9).
10. Pubmed Battaglioli E. et al. REST repression of neuronal genes requires components of the hSWI.SNF complex. J. Biol. Chem., 2002 Oct 25 , 277 (41038-45).
9. Pubmed Armisén R. et al. Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus. J. Neurosci., 2002 Oct 1 , 22 (8347-51).
8. Pubmed Sun Y. et al. Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis. J. Pept. Res., 2002 Nov , 60 (247-56).
7. Pubmed Alessandri-Haber N. et al. Molecular determinants of emerging excitability in rat embryonic motoneurons. J. Physiol. (Lond.), 2002 May 15 , 541 (25-39).
6. Pubmed Bouzidi M. et al. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes. J. Biol. Chem., 2002 Aug 9 , 277 (28996-9004).
5. Pubmed Hamon A. et al. Characterization of scorpion alpha-like toxin group using two new toxins from the scorpion Leiurus quinquestriatus hebraeus. Eur. J. Biochem., 2002 Aug , 269 (3920-33).
4. Pubmed Chen H. et al. Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. Eur. J. Neurosci., 2002 Aug , 16 (767-70).
3. Pubmed Ballas N. et al. Regulation of neuronal traits by a novel transcriptional complex. Neuron, 2001 Aug 16 , 31 (353-65).
2. Pubmed Shah B. et al. Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS. J. Physiol. (Lond.), 2001 Aug 1 , 534 (763-76).
1. Pubmed Baulac S. et al. A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. Am. J. Hum. Genet., 1999 Oct , 65 (1078-85).