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Differentially expressed genes in rat dorsal root ganglia following peripheral nerve injury.

D S Kim, S J Lee, S Y Park, H J Yoo, S H Kim, K J Kim, H J Cho

Neuroreport, 2001 Oct 29 , 12, 3401-5

Ordered differential display PCR was used to identify differentially expressed genes in rat dorsal root ganglia at 7 days following chronic constriction injury (CCI) of the sciatic nerve. Fourteen differentially displayed cDNA bands were isolated, cloned and verified by RT-PCR. The four mRNAs were increased, which included mRNAs encoding heat shock protein 27, fatty acid binding protein, apolipoprotein D and one novel gene. Six down-regulated clones were microtubule-associated protein 1B, protein tyrosine phosphatase alpha, Kv1.2 channel, myelin protein SR13, medium-sized neurofilament protein, and one novel gene. Our results show that many differentially regulated genes after CCI may play a role in nerve degeneration and/or regeneration and provide a molecular framework for understanding the peripheral mechanism underlying neuropathic pain.

http://www.ncbi.nlm.nih.gov/pubmed/11711894