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[Association between familial febrile convulsions and HCN2 gene]

Yi-Nang Ma, Zhi-Yue Chen, Li-Pin Zou, Ying Zhang, Shu-Lan Niu, Yu-Feng Xu, Pei Pei, Ding-fang Bu, Yu Qi

Zhonghua Yi Xue Za Zhi, 2005 Mar 16 , 85, 663-6

OBJECTIVE: To investigate the possible association of familial febrile convulsions with HCN2 gene. METHODS: PCR was conducted on the DNA of peripheral blood white cells from 60 children with familial febrile convulsion (FC) of Han nationality population in northern China aged 1.5 +/- 1.0 (8 months to 5 years old), to amplify the exons of HCN2 gene. The PCR products underwent sequencing to identify the possible mutations. 101 normal children from the same area were used as controls. RESULTS: No mutation was found in the exons of HCN2 gene, however, 14 single nucleotide polymorphisms (SNPs) were found among which there were 8 newly identified SNPs. Using 9 SNPs as markers, association study was conducted between the FC group and control group. There were no significant differences in allele frequencies and genotype frequencies of the 9 SNPs between the FC group and control group. CONCLUSION: HCN2 may not be a susceptibility gene for FC in Chinese population.