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Regulation of voltage-gated Ca2+ channels by calmodulin.

D Brent Halling, Paula Aracena-Parks, Susan L Hamilton

Sci. STKE, 2006 Jan 17 , 2006, er1

Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 andCav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels.

http://www.ncbi.nlm.nih.gov/pubmed/16685765