Cav3.1 is a T type calcium channel, also know as a1G. It is a low voltage activated (LVA) calcium channel found in neurons and cardiac tissue.
Calcium channels are multimeric proteins consisting of a
pore forming alpha-1 subunit and some combination of auxiliary
beta, alpha-2delta and gamma subunits . Multiple genes and gene splice
variants encode members of each subunit family. The exten-
sive biophysical and pharmacological diversity of native calcium currents can be attributed to variation in their molecular
Cacna1g : calcium channel, voltage-dependent, T type, alpha 1G subunit
Cytoplasm situated near, or occurring around, the nucleus.
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
neuronal cell body
The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites.
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
Zn2+ influences human CaV 3.1, CaV 3.2 and CaV 3.3 channels. It causes for example a significant increase in CaV 3.3 current in action potential clamp experiments, while CaV 3.1 and CaV 3.2 currents are significantly reduced.
Gamma6 isoforms have a unique negative effect on Cav3.1 low voltage activated current density that is not seen with either gamma4 or gamma7. 
Cav3.1 is expressed in rat cardiac myocytes and presumably contributes to the generation of the native cardiac low voltage activated calcium current .
T-type Ca2+ channels are involved in cardiac
pacemaker activity , , neuronal firing activity , sleep
, hormone secretion  and fertilization . T-type Ca2+ channels are also implicated
in the pathogenesis of epilepsy , pain  and cardiac
T-type Ca2+ channels correspond to a subfamily of
voltage-gated Ca2+ channels with specific hallmarks:
low-voltage activation, transient inactivation kinetics and
small unitary conductance .