calcium channel, voltage-dependent, R type, alpha 1E subunit Synonyms: cacna1e cav2.3 ca2.3. Symbol: Cacna1e
The R type calcium channel, also know as a1E or Cav2.3, is an HVA calcium channel found in neurons. R-type Ca2+ currents have been pharmacologically defined
by their resistance to blockers of L-type, N-type, and P/Q-type Ca2+ channels  and by their sensitivity to SNX-482, a peptide component of spider venom .
GeneID: 54234 Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit [ Rattus norvegicus ]
Cacna1e : calcium channel, voltage-dependent, R type, alpha 1E subunit
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
The portion of the cell soma (cell body) that excludes the nucleus.
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
G-alpha-q/11-coupled Muscarinic Acetylcholine
Cav2.3 is both inhibited and stimulated through G-alpha-q/11-coupled muscarinic acetylcholine receptors , .
Interaction with alpha1C channel
A chimeric channel containing the I-II linker from alpha1E (Cav2.3) accelerated the inactivation kinetics of alpha1C .
Mibefradil (RO 40-5967), which has been used clinically as an anti-hypertensive
and antianginal agent is modulating Ca2.3's inactivation kinetics. 
Point mutationins R387E in alpha1E channels significantly influence both the kinetics and the voltage dependence of inactivation. 
Altogether our findings identify S6
hydrophobic residues in Domains I to IV that play a unique role
in controlling the relative stability of the open and closes states
in CaV2.3. 
Cav2.3 channels are located in dendritic spines. 
Cav2.3 is involved in cerebellar function, morphine tolerance, and synaptic plasticity , , , ,
. It is noteworthy that CaV2.3 is also
implicated in nociception, as evidenced by the fact that
CaV2.3 knockout mice exhibit functional deficits in pain per-
ception  and intrathecal injection of
SNX-482 produces analgesia .
R-type currents - mediated by Cav2.3 channels - participate in neurosecretion and in the formation of afterdepolarizations, plateau potentials, and bursting activity in hippocampal CA1 pyramidal neurons , , , .