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Cav2.3

calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: cacna1e cav2.3 ca2.3. Symbol: Cacna1e

Introductions


The R type calcium channel, also know as a1E or Cav2.3, is an HVA calcium channel found in neurons. R-type Ca2+ currents have been pharmacologically defined by their resistance to blockers of L-type, N-type, and P/Q-type Ca2+ channels [512] and by their sensitivity to SNX-482, a peptide component of spider venom [513].

Genes


GeneID: 54234 Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit [ Rattus norvegicus ]

Cacna1e : calcium channel, voltage-dependent, R type, alpha 1E subunit

RGD ID Chromosome Position Species
2246 13 69367254-69683943 Rat
733703 1 156239649-156573050 Mouse
733702 1 181452716-181770716 Human

Transcripts


Acc No Sequence Length Source
NM_019294 NCBI
NM_009782 NCBI
NM_000721 NCBI

Ontologies


Accession Name Definition Evidence
GO:0005891 voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. TAS
GO:0043204 perikaryon The portion of the cell soma (cell body) that excludes the nucleus. IDA
GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA

Interactions


G-alpha-q/11-coupled Muscarinic Acetylcholine

Cav2.3 is both inhibited and stimulated through G-alpha-q/11-coupled muscarinic acetylcholine receptors [526], [89].

Interaction with alpha1C channel

A chimeric channel containing the I-II linker from alpha1E (Cav2.3) accelerated the inactivation kinetics of alpha1C [527].

Mibefradil

Mibefradil (RO 40-5967), which has been used clinically as an anti-hypertensive and antianginal agent is modulating Ca2.3's inactivation kinetics. [100]

Proteins


Structures


Point mutationins R387E in alpha1E channels significantly influence both the kinetics and the voltage dependence of inactivation. [97]

Altogether our findings identify S6 hydrophobic residues in Domains I to IV that play a unique role in controlling the relative stability of the open and closes states in CaV2.3. [99]

Distributions


Cav2.3 channels are located in dendritic spines. [518]

Expressions


Functionals


Cav2.3 is involved in cerebellar function, morphine tolerance, and synaptic plasticity [519], [520], [521], [522], [523]. It is noteworthy that CaV2.3 is also implicated in nociception, as evidenced by the fact that CaV2.3 knockout mice exhibit functional deficits in pain per- ception [524] and intrathecal injection of SNX-482 produces analgesia [525].

Kinetics


R-type currents - mediated by Cav2.3 channels - participate in neurosecretion and in the formation of afterdepolarizations, plateau potentials, and bursting activity in hippocampal CA1 pyramidal neurons [514], [515], [516], [517].

Models


[1] Ca_R (Model ID = 7)

Animalrat 46
CellType Cerebellar
Age 21 Days
Temperature36.0°C
Reversal 135.0 mV
Ion Ca +
Ligand ion
Reference T Miyasho et. al; Brain Res. 2001 Feb 9
mpower 1.0
mAlpha 2.6/(1+exp((v+7)/-8))
mBeta 0.18/(1+exp((v+26)/4))
hpower 1.0
hAlpha 0.0025/(1+exp((v+32)/8))
hBeta 0.19/(1+exp((v+42)/-10))

MOD xml channelML

References


[97 : 11159396]
[98 : 18443816]
[89 : 17050807]
[99 : 17660294]
[100 : 11719851]
[101 : 12645522]
[102 : 12202369]
[261 : 11164813]
[340 : 9257934]
[512 : 8107963]
[513 : 9799496]
[514 : 12410316]
[515 : 15816941]
[516 : 15958743]
[517 : 16763032]
[518 : 11117746]
[519 : 11263998]
[520 : 14519849]
[521 : 12895422]
[522 : 15610184]
[523 : 16631598]
[524 : 10801976]
[525 : 15451373]
[526 : 10436038]
[527 : 10823819]

Credits


Editor : Admin.

Contributors : Rajnish Ranjan, Michael Schartner

To cite : [Editor], [Contributors]. Accessed on [Date] Channelpedia , http://channelpedia.epfl.ch/ionchannels/82