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Cav1.3

calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: cacna1d cav1.3 ca1.3. Symbol: Cacna1d

Introductions


Cav1.3 is an L type, high voltage activated (HVA) calcium channel found in the certain neuronal dendrites. It is also known as a1E. Its role in hair cells has been studied [228], [229].

Four L-type voltage gated Ca channels (LTCC) isoforms evolved (termed Cav1.1, Cav1.2, Cav1.3, and Cav1.4). All of them are characterized by high sensitivity to dihydropyridine (DHP) Ca2+ channel modulators, although differences in their voltage-dependence of DHP block exist [511]. This unique DHP sensitivity distinguishes them from other voltage-gated Ca2+ channel types (non-LTCCs). LTCC isoforms differ considerably with respect to their gating properties and tissue expression [511]. The gating differences are intrinsic properties of their pore-forming alpha-1 subunits which assemble with accessory alpha-2-delta and beta-subunits (and in some tissues also a gamma-subunit) to form a functional channel complex [511].

Genes


Cacna1d : calcium channel, voltage-dependent, L type, alpha 1D subunit

RGD ID Chromosome Position Species
70973 16 5383259-5703361 Rat
735458 14 30853125-31304342 Mouse
735457 3 53529031-53846492 Human

Transcripts


Acc No Sequence Length Source
NM_017298 NCBI
NM_028981 NCBI
NM_001083616 NCBI
NM_001128840 NCBI
NM_001128839 NCBI
NM_000720 NCBI

Ontologies


Accession Name Definition Evidence
GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA
GO:0005891 voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. TAS
GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA
GO:0016324 apical plasma membrane The region of the plasma membrane located at the apical end of the cell. IDA

Interactions


Dihydropyridine

All L-type voltage gated Ca channels are characterized by high sensitivity to dihydropyridine (DHP) Ca2+ channel modulators, although differences in their voltage-dependence of DHP block exist [511].

L-type Dihydropyridine Antagonists

Cav1.3 is insensitive to the L-type dihydropyridine antagonists. [506]

Nifedipine and Bay K 8644

Nifedipine and Bay K 8644, respectively, block Cav1.3 channels. [230]

Proteins


Structures


Distributions


Calcium channels are clustered at synaptic release sites.[505]

Expressions


Cav1.3 can be found in auditory sensory hair cells, [505], neuronal cells and some epithelial cells [228]. In particular in the chick auditory papilla [507], frog saccule [508], trout saccule and mammalian cochlea [509], [510], [506].

Only L-type channels are present in turtle auditory hair cells. [228]

Functionals


Calcium channels are fundamental to signal processing in auditory sensory hair cells [511], regulating both the membrane excitability and neurotransmitter release [505].

Kinetics


Cav1.3 have a hyperpolarized activation curve and fast (submillisecond) activation rise times. [506]

Models


References


[228 : 12740421]
[229 : 18174213]
[230 : 14514878]
[505 : 1700083]
[506 : 11285265]
[507 : 9405708]
[508 : 11483699]
[509 : 10601462]
[510 : 10929716]
[511 : 15336981]
[498 : 14657414]

Credits


Editor : Admin.

Contributors : Rajnish Ranjan, Michael Schartner

To cite : [Editor], [Contributors]. Accessed on [Date] Channelpedia , http://channelpedia.epfl.ch/ionchannels/81