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Nav2.2


Synonyms: nav2.2. Symbol:

Introductions


Nav2.2 ( also known as Scn7A, Na-G) is expressed in astrocytes of rat CNS.

The mammalian sodium channel isoforms that have been identified thus far can be subdivided into three main groups. The type 1 channels (Nav1.x) share significant sequence similarity with each other,4 and all but one have been functionally expressed in exogenous systems. The type 2 channels (Nav2.x) are approximately 50% identical to the type 1 channels, with significant differences in regions that are critical for channel function. [873] None of these channels have been expressed in an exogenous system before 1999, so that it was not possible to draw any conclusions about the properties of these channels before 1999. [881]

Genes


Scn7A may represent the same gene as Scn6A, since only one full-length cDNA has been isolated for these two genes from any single species. [880]

Gene bank access is M96578 under its original name Na-G [882], and Y09164 under its original name SCL11 [879]. [881]

The phylogenetic relationship of mammalian voltage-gated sodium channel alpha subunit genes, including Scn7A can be found at [880].

:

RGD ID Chromosome Position Species

Transcripts


Acc No Sequence Length Source

Ontologies


Accession Name Definition Evidence

Interactions


Proteins


Structures


See figure 1 in Goldin 2000 [878] for a transmembrane folding diagram displaying the structure of a generic voltage gated sodium alpha subunit.

Distributions


Expressions


In the rat brain, Nav2.2 can be found in astrocytes and PNS (DRG). [881]

Functionals


Kinetics


Models


References


[878 : 11144347]
[880 : 10198179]
[881 : 10414280]
[879 : 9001394]
[882 : 1379737]
[873 : 1317577]

Credits