SCN7A (also known as SCN6A) encodes the voltage gated, type 7, sodium channel alpha unit Nav2.1.
The 7.2-kilobase cDNA sequence, designated hNav2.1, predicts a 1682-amino acid protein that bears 52%, 49%, and 46% overall identity with sodium
channels cloned from rat brain, skeletal muscle, and heart,
Until recently, all cloned vertebrate voltage-dependent sodium channels exhibited high sequence homology to one another and appeared to comprise a single multigene subfamily. An exception is the human Nav2.1 channel proposed to represent a second Na+ channel (NaCh) gene subfamily since comparison with previously cloned voltage-gated NaChs revealed only 40-45% identity. 
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Positively charged S4 segments are present in
hNav2. 1, but there are fewer basic residues in repeat domains
1, 3, and 4 than in other cloned sodium channels. 
Attempts to express functional Nav2.1
channels using heterologous expression systems such as Xenopus
oocytes, Chinese hamster ovary cells, and human embryonic
kidney-293 cells have been unsuccessful , , suggesting the
requirement of an as-yet unidentified partner. 
Nav2.1 is prominently expressed in
both heart and uterus. 
mNav2.3 mRNA was most abundant in heart and uterus, and the transcript levels in heart, brain, and skeletal muscle were differentially regulated during development. Transcript levels in heart were greatest immediately after birth. mNav2.3 transcript levels in pregnant uterus increased 3-fold between day 15 of pregnancy and birth and then declined 15-fold during the 2 days following delivery. 
Brugada syndrome, first described in 1992, has a high risk of
sudden cardiac death. Nav2.1 was strongly
expressed in the hearts of patients with Brugada syndrome. 
Gaborit claimed 2008  that Nav2.1 is a Na-channel with
unknown function so far.