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CHO

Chinese Hamster Ovary Cells
Synonyms: CHO.

Introductions


CHO cells are a line of epithelial-like cells that was initiated in 1957 by T.T. Puck and colleagues at the Department of Biophysics, University of Colorado Medical School in Denver, USA from a biopsy of an ovary of an adult Chinese hamster [1352]. There are several specific features that make the CHOcell line one of the most convenient solutions for reconstitution of mammalian ionchannels and related proteins: 1) it is a mammalian cell line; 2) they are adherent cells that make them easier to transfect compared to cell lines that grow in suspension; 3) cells are not electrotonically coupled and so are easy to voltage clamp, and 4) they express very little endogenous currents. [1353]

Morphologies


Genes


Proteins


Ion channels


TRPM4, KCNK5, Kir, Neglegible Ik.

Functions


Electrophysiologies


Models


References


[1352]
[1353]
[1354]
[1355]

Credits